Estrogen metabolism and action in endometriosis

Rizner TL, Tea Lanisnik Rizner, Tea Lanišnik Rižner
Molecular and cellular endocrinology · 2009 · vol. 307(1-2) , pp. 8–18 · doi:10.1016/j.mce.2009.03.022 · PMID:19524121 · W2163825655
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This paper investigates estrogen metabolism and its role in the development and progression of endometriosis.

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Abstract

Endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial glands and stroma outside the uterine cavity. The etiology of endometriosis is multifactorial and includes complex interactions of genetic, immunological, hormonal and environmental factors. Many theories have been proposed, but no single theory can explain all aspects of endometriosis, suggesting that endometriosis is a heterogeneous disease. This review presents the current theories on the pathogenesis of endometriosis, followed by an overview on estrogen metabolism in normal endometrium and diseased endometrium of endometriosis patients. The potential role of aberrant expression of individual estrogen-metabolizing enzymes is discussed, and a model mechanism for increased formation of estradiol is presented separately for different types of endometriosis. The disturbed expression of estrogen receptors in endometriosis is detailed, and the estrogen biosynthetic enzymes and receptors are discussed as novel therapeutic targets for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogens Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrogens Estrogens Estrogens Female Humans Receptors, Estrogen Receptors, Estrogen

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

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License: CC0 · commercial use OK