A Mendelian randomization approach to study the causal association between four types of endometriosis and immune cells: experimental studies

Wangshu Li, Wang X, Xiuying Wang, Xu Zhang, Zhang X, Sun S, Shu Sun, Jiuxiang Feng, Feng J, Aziz AUR, Aziz ur Rehman Aziz
International journal of surgery (London, England) · 2024 · vol. 111(1) , pp. 1461–1465 · doi:10.1097/js9.0000000000001909 · PMID:38959091 · PMC11745679 · W4400278671
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This Mendelian randomization study investigated the causal association between four types of endometriosis and immune cell counts, using genetic variants to infer causal relationships.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This paper uses a Mendelian randomization framework to assess causal associations between four types of endometriosis and immune cell traits, leveraging publicly available genetic data and genome-wide summary statistics to infer directionality. The authors’ key finding is not provided in the excerpt, but the study is structured around estimating immune-cell effects for genetically instrumented exposures representing distinct endometriosis types. A major caveat typical of Mendelian randomization—such as validity of genetic instruments and potential confounding/pleiotropy—is not stated in the provided text, so limitations cannot be detailed from the excerpt alone. This paper is centrally about endometriosis — it investigates causal links between multiple endometriosis types and immune cells using Mendelian randomization.

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Abstract

Li, Wangshu; Wang, Xiuying; Zhang, Xu; Sun, Shu; Feng, Jiuxiang; Aziz, Aziz ur Rehman PhD Author Information
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Author

W.L.: data curation, funding acquisition, investigation, methodology, and writing – original draft; X.W.: conceptualization, resources, and writing – review and editing; X.Z.: data curation, methodology, and writing – original draft; S.S.: writing – original draft; J.F.: conceptualization, project administration, and writing – review and editing; A.R.A.: conceptualization, data curation, supervision, and writing – review and editing. All authors have read and approved the final manuscript for publication.

Source

This study was supported by the Dalian City Outstanding Young Science and Technology Talent Program, No. 2023RY020.

Consent

Not applicable.

Ethical

All the data are publicly available and no ethical approval or consent for publication was required.

Research

Not applicable.

Guarantor

Wangshu Li.

Provenance

Not commissioned.

Coi Statement

The authors declare that they have no conflicts of interest.

Data Availability

Publicly available datasets were analyzed in this study and all the details are provided in the manuscript. For additional information or queries, interested parties are encouraged to reach out to the corresponding author.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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