Biomarkers of endometriosis

Hafiz Muhammad Arsalan; Arsalan HM; Mumtaz H; Hina Mumtaz; Antonio Simone Lagana; Lagana AS; Antonio Simone Laganà

doi:10.1016/bs.acc.2025.01.004

Biomarkers of endometriosis

Hafiz Muhammad Arsalan, Arsalan HM, Mumtaz H, Hina Mumtaz, Antonio Simone Lagana, Lagana AS, Antonio Simone Laganà

Advances in clinical chemistry · 2025 · vol. 126 , pp. 73–120 · doi:10.1016/bs.acc.2025.01.004 · PMID:40185537 · W4408476507

review OA: closed CC0 ⤵ 2 in-corpus citations

View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper investigated biomarkers associated with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis represents a diverse disease characterized by three distinct phenotypes: superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis. The most widely accepted pathophysiological hypothesis for endometriosis is rooted in retrograde menstruation, a phenomenon observed in most patients. Endometriosis is closely linked to infertility, but having endometriosis does not necessarily imply infertility. The disease can impact fertility through various mechanisms affecting the pelvic cavity, ovaries, and the uterus itself. MicroRNAs (miRNAs) indeed represent a fascinating and essential component of the regulatory machinery within cells. Discovered in the early 1990s, miRNAs have since been identified as critical players in gene expression control. Unfortunately, ovarian endometrioma is a common gynecologic disorder for which specific serum markers are currently lacking. Some have examined urocortin for its ability to differentiate endometriomas from other benign ovarian cysts. Another potential marker, Cancer Antigen 125 (CA-125) is a well-established indicator for epithelial cell ovarian cancer and its levels can be elevated in conditions such as endometriosis. CA-125 is derived from coelomic epithelia, including the endometrium, fallopian tube, ovary, and peritoneum. In this review we examine the pathophysiologic basis for endometriosis and highlight potential markers to more fully characterize the underlying biochemical processes linked to this multifaceted disease state.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (3)

Source provenance

europepmc: last seen: 2026-07-25T06:15:30.875455+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-07-25T06:11:17.533620+00:00

License: CC0 · commercial use OK

[1] 1H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis via openalex

[2] Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition via openalex

[3] Adenomyosis and risk of preterm delivery via openalex

[4] Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis via openalex

[5] Analysis of Serum microRNA Profile by Solexa Sequencing in Women With Endometriosis via openalex

[6] An endometriosis classification, designed to be validated via openalex

[7] An Expanded Classification of Endometriosis via openalex

[8] A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine via openalex

[9] Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients via openalex

[10] Association of Endometriosis and Adenomyosis: Vast Literature but Scant Conclusive Data via openalex

[11] Association of History of Surgery for Endometriosis With Severity of Deeply Infiltrating Endometriosis via openalex

[12] A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes via openalex

[13] Biomarkers of endometriosis via openalex

[14] Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study via openalex

[15] ‘Blood On The Tracks’ from corpora lutea to endometriomas* via openalex

[16] Bowel anastomosis leakage following endometriosis surgery: an evidence based analysis of risk factors and prevention techniques. via openalex

[17] Bowel occult microscopic endometriosis in resection margins in deep colorectal endometriosis specimens has no impact on short-term postoperative outcomes via openalex

[18] CA-125 concentration in serum and peritoneal fluid in patients with endometriosis – preliminary results via openalex

[19] Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex

[20] “Centers of excellence in endometriosis surgery” or “centers of excellence in endometriosis” via openalex

[21] Central and Peripheral Pain Generators in Women with Chronic Pelvic Pain: Patient Centered Assessment and Treatment via openalex

[22] Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β<sub>2</sub> via openalex

[23] Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis via openalex

[24] Clinical evaluation of CA-125 concentrations as a prognostic factor for pregnancy in infertile women with surgically treated endometriosis via openalex

[25] Clinical Management of Bowel Endometriosis via openalex

[26] Clinical Management of Endometriosis via openalex

[27] Cystic ovarian endometriosis and infertility: arguments for an early but less aggressive surgical treatment via openalex

[28] Deep Infiltrating Endometriosis: Comparison Between 2‐Dimensional Ultrasonography (US), 3‐Dimensional US, and Magnetic Resonance Imaging via openalex

[29] Deep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease via openalex

[30] Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis via openalex

[31] Diagnosis of deep endometriosis by clinical examination during menstruation and plasma CA-125 concentration via openalex

[32] Differences in characteristics among 1,000 women with endometriosis based on extent of disease via openalex

[33] Disparity in endometriosis diagnoses between racial/ethnic groups via openalex

[34] Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis via openalex

[35] Emerging role of genomics in endometriosis research via openalex

[36] Endocrine disrupting chemicals and endometriosis via openalex

[37] Endometriosis via openalex

[38] Endometriosis via openalex

[39] Endometriosis after menopause: physiopathology and management of an uncommon condition via openalex

[40] Endometriosis also affects the decidua in contact with the fetal membranes during pregnancy via openalex

[41] Endometriosis and adverse maternal, fetal and neonatal outcomes, a systematic review and meta-analysis via openalex

[42] Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women via openalex

[43] Endometriosis and infertility: pathophysiology and management via openalex

[44] Endometriosis and obstetrics complications: a systematic review and meta-analysis via openalex

[45] Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery via openalex

[46] Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications via openalex

[47] Endometriosis and pregnancy complications: a Danish cohort study via openalex

[48] Endometriosis: Appearance and detection with conventional and contrast‐enhanced fat‐suppressed spin‐echo techniques via openalex

[49] Endometriosis as a model for inflammation–hormone interactions in ovarian and breast cancers via openalex

[50] Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex

[51] Endometriosis of the Appendix: When to Predict and How to Manage—A Multivariate Analysis of 1935 Endometriosis Cases via openalex

[52] Endometriosis: pathogenesis and treatment via openalex

[53] Endometriosis-related infertility: ovarian endometrioma<i>per se</i>is not associated with presentation for infertility via openalex

[54] Endometriotic ovarian cysts do not negatively affect the rate of spontaneous ovulation via openalex

[55] Endotoxin aggression in the pathogenesis of chronic inflammatory diseases of small pelvis organs and infertility, or an antiendotoxin approach to their treatment via openalex

[56] Epidemiology of subtle, typical, cystic, and deep endometriosis: a systematic review via openalex

[57] Estrogen metabolism and action in endometriosis via openalex

[58] Evidence-Based Medicine: Pandora's Box of Medical and Surgical Treatment of Endometriosis via openalex

[59] Fecundity of Infertile Women with Minimal or Mild Endometriosis And Women with Unexplained Infertility via openalex

[60] Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium via openalex

[61] Functional Connectivity Is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain via openalex

[62] Functional MicroRNA Involved in Endometriosis via openalex

[63] Genetic influences on endometriosis in an Australian twin sample via openalex

[64] Genetics of Endometriosis via openalex

[65] Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 via openalex

[66] Heritability of endometriosis via openalex

[67] Imaging modalities for the non-invasive diagnosis of endometriosis via openalex

[68] Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via openalex

[69] Impact of endometriosis on women's health: comparative historical data show that the earlier the onset, the more severe the disease via openalex

[70] Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis via openalex

[71] Increased levels of dioxin-like substances in adipose tissue in patients with deep infiltrating endometriosis via openalex

[72] Increased Numbers of Activated Mast Cells in Endometriosis Lesions Positive for Corticotropin‐Releasing Hormone and Urocortin via openalex

[73] Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. via openalex

[74] Inflammation and nerve fiber interaction in endometriotic pain via openalex

[75] Influence of adenomyosis on pregnancy and perinatal outcomes in women with endometriosis via openalex

[76] Insights into Assessing the Genetics of Endometriosis via openalex

[77] Interleukin-1: a possible role in the infertility associated with endometriosis via openalex

[78] INTESTINAL ADENOMAS OF ENDOMETRIAL TYPE via openalex

[79] Intraperitoneal inflammation decreases endometriosis in a mouse model via openalex

[80] In women with endometriosis anti-Mullerian hormone levels are decreased only in those with previous endometrioma surgery via openalex

[81] Is adolescent endometriosis a progressive disease that needs to be diagnosed and treated? via openalex

[82] Is mild endometriosis a disease?: Is mild endometriosis a condition occurring intermittently in all women? via openalex

[83] Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex

[84] Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis via openalex

[85] Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis via openalex

[86] Long-term follow-up after conservative surgery for rectovaginal endometriosis via openalex

[87] Magnetic Resonance Imaging and Endometriosis: Deeply Infiltrating Endometriosis Does Not Originate from the Rectovaginal Septum via openalex

[88] Management of endometriomas via openalex

[89] Management of endometriosis from diagnosis to treatment: roadmap for the future via openalex

[90] Management of Endometriosis in the Infertile Patient via openalex

[91] Management of Endometriosis in the Infertile Patient via openalex

[92] Micrometastasis of endometriosis to distant organs in a murine model via openalex

[93] MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors via openalex

[94] MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis via openalex

[95] MicroRNA-Regulated Pathways Associated with Endometriosis via openalex

[96] microRNAs and angiogenesis in endometriosis via openalex

[97] MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK /NF- B pathway and reduced interleukin-8 expression via openalex

[98] Müllerianosis: Four Developmental (Embryonic) Müllerian Diseases via openalex

[99] Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis via openalex

[100] Nonpigmented endometriosis: Clinical, laparoscopic, and pathologic definition via openalex