Endometriosis and obstetrics complications: a systematic review and meta-analysis

Fabrizio Zullo, Spagnolo E, Emanuela Spagnolo, Gabriele Saccone, Acunzo M, Miriam Acunzo, Serena Xodo, Xodo S, Marcello Ceccaroni, Vincenzo Berghella
Fertility and sterility · 2017 · vol. 108(4) , pp. 667–672.e5 · doi:10.1016/j.fertnstert.2017.07.019 · PMID:28874260 · W2751185666
review OA: bronze CC0 ⤵ 155 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This systematic review and meta-analysis examined the association between endometriosis and various obstetrical complications.

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Abstract

ObjectiveTo evaluate the effect of endometriosis on pregnancy outcomes.DesignSystematic review and meta-analysis.SettingNot applicable.Patient(s)Women with or without endometriosis.Intervention(s)Electronic databases searched from their inception until February 2017 with no limit for language and with all cohort studies reporting the incidence of obstetric complications in women with a diagnosis of endometriosis compared with a control group (women without a diagnosis of endometriosis) included.Mean outcome measure(s)Primary outcome of incidence of preterm birth at <37 weeks with meta-analysis performed using the random effects model of DerSimonian and Laird to produce an odds ratio (OR) with 95% confidence interval (CI).Result(s)Twenty-four studies were analyzed comprising 1,924,114 women. In most of them, the diagnosis of endometriosis was made histologically after surgery. Women with endometriosis had a statistically significantly higher risk of preterm birth (OR 1.63; 95% CI, 1.32-2.01), miscarriage (OR 1.75; 95% CI, 1.29-2.37), placenta previa (OR 3.03; 95% CI, 1.50-6.13), small for gestational age (OR 1.27; 95% CI, 1.03-1.57), and cesarean delivery (OR 1.57; 95% CI, 1.39-1.78) compared with the healthy controls. No differences were found in the incidence of gestational hypertension and preeclampsia.Conclusion(s)Women with endometriosis have a statistically significantly higher risk of preterm birth, miscarriage, placenta previa, small for gestational age infants, and cesarean delivery.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Obstetric Labor Complications Pregnancy Complications Endometriosis Endometriosis Female Humans Incidence Infant, Newborn Obstetric Labor Complications Obstetric Labor Complications Pregnancy Pregnancy Complications Pregnancy Complications Pregnancy Outcome Pregnancy Outcome Reproductive Techniques, Assisted Reproductive Techniques, Assisted

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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