Endometriosis and risk factors in pregnancy, labor and delivery: a case-control study

Carlo Alboni, Marianna Cannoletta, Sara Mosca, Silvia Pasini, Antonino Farulla, Giuseppe Chiossi
Minerva obstetrics and gynecology · 2024 · vol. 76(6) , pp. 540–547 · doi:10.23736/s2724-606x.24.05527-1 · PMID:39512100 · W4404193430
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This case-control study found that women with endometriosis experienced higher rates of gestational hypertension, pre-eclampsia, placenta previa, and postpartum hemorrhage compared to controls, but no increased risk of cesarean delivery.

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Abstract

BACKGROUND: It is a common thought that endometriosis and its related pain symptoms could improve during pregnancy. However, endometriosis was shown to affect the regular development of pregnancy and delivery outcomes. Several adverse events may occur in the peri-implantation period, and may perpetuate throughout the pregnancy of patients diagnosed with the disease. METHODS: We analyzed pregnancy, delivery and neonatal outcomes in two groups of patients (case and control group), a total of 91 women with endometriosis were 1:3 matched to 273 controls by age. Diagnosis of endometriosis was histologically confirmed and a database with general medical and gynecological history, pregnancy course, delivery mode and newborn conditions was analyzed. RESULTS: Patients with endometriosis presented higher rates of gestational hypertension (4.4% vs. 0.8%, P=0.02), pre-eclampsia (2.2% vs. 0, P=0.014) and placenta previa (3.3% vs. 0, P=0.003). Caesarean delivery (29.6% vs. 11.3%, P value <0.01) and postpartum hemorrhage (26.5% vs. 11.9%, P=0.04) were more common among patients diagnosed with endometriosis. Multivariate logistic regression showed that cesarean delivery was associated with endometriosis, hypertension and prior cesarean delivery. Postpartum hemorrhage is significantly higher in women treated for endometriosis (26.5% vs. 11.9%, P=0.037). CONCLUSIONS: Endometriosis is related to a higher risk of preeclampsia, placenta previa and postpartum bleeding but it does not increase the risk of cesarean delivery during labor. Obstetricians should consider such associations when managing pregnant patients with a history of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Pregnancy Complications Pregnancy Complications Pregnancy Complications Pregnancy Complications Pregnancy Complications Pregnancy Complications

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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