Adenomyosis and risk of preterm delivery

C M Juang, C-M Juang, Po‐Yen Chou, P Chou, M-S Yen, N-F Twu, H‐C Horng, H-C Horng, W-L Hsu, W‐L Hsu
BJOG: An International Journal of Obstetrics & Gynaecology · 2006 · vol. 114(2) , pp. 165–169 · doi:10.1111/j.1471-0528.2006.01186.x · PMID:17169011 · W2088260572
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Gravid women with adenomyosis had a significantly increased risk of overall preterm delivery, spontaneous preterm delivery, and preterm premature rupture of membranes.

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Abstract

OBJECTIVE: To evaluate the risk of preterm delivery in patients with adenomyosis. DESIGN: A 1:2 nested case-control study. SETTING: Tertiary-care institution. POPULATION: A base cohort population of 2138 pregnant women who attended routine prenatal check-up between July 1999 and June 2005. METHODS: From this base cohort population, gravid women with singleton pregnancy who delivered prior to the completion of 37 weeks of gestation were identified and formed the study group. Singleton gravid women who had term delivery and who matched with age, body mass index, smoking, and status of previous preterm delivery were recruited concurrently and served as control group. Preterm delivery cases were further divided into spontaneous preterm delivery and preterm premature rupture of membranes (PPROM) cases. MAIN OUTCOME MEASURES: Risk analysis of preterm delivery between gravid women with and without adenomyosis. RESULTS: One-hundred and four preterm delivery case subjects and 208 control subjects were assessed. Overall, gravid women with adenomyosis were associated with significantly increased risk of preterm delivery (adjusted odds ratio 1.96, 95% CI 1.23-4.47, P=0.022). For subgroup analysis, gravid women with adenomyosis had an adjusted 1.84-fold risk of spontaneous preterm delivery (95% CI 1.32-4.31, P=0.012) and an adjusted 1.98-fold risk of PPROM (95% CI 1.39-3.15, P=0.017). CONCLUSIONS: Gravid women with adenomyosis were associated with increased risk of both spontaneous preterm delivery and PPROM. A common pathophysiological pathway may exist in these two disorders. Further in-depth biochemical and molecular studies are necessary to explore this phenomenon.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Myometrium Premature Birth Uterine Neoplasms Case-Control Studies Endometriosis Female Humans Pregnancy Premature Birth Risk Factors Uterine Neoplasms

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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