The Therapeutic Effect of HIFU on Adenomyosis

In: Adenomyosis · 2021 · pp. 137–141 · doi:10.1007/978-981-33-4095-4_15 · W3130021939
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-12

This chapter reviews the efficacy and safety of high-intensity focused ultrasound (HIFU) as a treatment for adenomyosis, considering symptom improvement and obstetric outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text

This paper is a 2021 chapter that reviews the therapeutic effects of high-intensity focused ultrasound (HIFU) for uterine adenomyosis, focusing on symptom improvement (e.g., dysmenorrhea, chronic pelvic pain, dyspareunia, menstrual abnormalities, and pressure symptoms from uterine enlargement) and on safety and outcomes relevant to fertility and pregnancy. It discusses the clinical burden of adenomyosis and summarizes evidence from prior studies, while explicitly noting that treatment effectiveness should be evaluated alongside method safety and improvements in symptoms and obstetric outcomes. The chapter’s main limitation is that it is a narrative review rather than a new controlled study, so its conclusions depend on the heterogeneous evidence base it compiles. This paper is centrally about endometriosis and/or adenomyosis—specifically adenomyosis—and it reviews HIFU as a non-invasive treatment for adenomyosis symptoms and related fertility/pregnancy outcomes.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 4,859 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

About 70% of patients with adenomyosis have clinical symptoms, including pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, and menstrual abnormalities as increased menstrual bleeding and prolonged menstrual period. It may also produce pressure symptoms due to the uterine enlargement caused by adenomyosis [1]. A large number of studies have also confirmed that adenomyosis can affect women’s pregnancy and fertility, including subfertility and even infertility, as well as affect adverse obstetric outcomes, such as miscarriage, premature delivery, premature rupture of membranes, and also affect the treatment outcomes of in vitro fertilization [2–5]. These clinical symptoms are often the reasons for the patient’s consultation visits. When evaluating the treatment effectiveness of adenomyosis, on the one hand, the safety of the method must be considered. On the other hand, the improvement of the above symptoms and obstetrics outcomes should also be evaluated. As a new treatment method for adenomyosis, we should consider HIFU, not only its non-invasive approach but also its safety and effectiveness. Here we summarize the efficacy of HIFU treatment for adenomyosis in this chapter. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Gordts S, Grimbizis G, Campo R. Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertil Steril. 2018;109(3):380–388. e1. Matalliotakis IM, Katsikis IK, Panidis DK. Adenomyosis: what is the impact on fertility? Curr Opin Obstet Gynecol. 2005;17(3):261–4. Maheshwari A, et al. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update. 2012;18(4):374–92. Juang CM, et al. Adenomyosis and risk of preterm delivery. BJOG Int J Obstet Gynaecol. 2007;114(2):165–9. Younes G, Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril. 2017;108(3):483–490.e3. Yang Z, et al. Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis. Fertil Steril. 2009;91(6):2338–43. Yoon S-W, et al. Successful use of magnetic resonance–guided focused ultrasound surgery to relieve symptoms in a patient with symptomatic focal adenomyosis. Fertil Steril. 2008;90(5):2018. e13–5. Zhou M, et al. Ultrasound-guided high-intensity focused ultrasound ablation for adenomyosis: the clinical experience of a single center. Fertil Steril. 2011;95(3):900–5. Lee J-S, et al. Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: a single center experience from the Republic of Korea. Ultrason Sonochem. 2015;27:682–7. Marques ALS, et al. Is high-intensity focused ultrasound effective for the treatment of adenomyosis? A systematic review and meta-analysis. J Minim Invasive Gynecol. 2020;27(2):332–43. Shui L, et al. High-intensity focused ultrasound (HIFU) for adenomyosis: two-year follow-up results. Ultrason Sonochem. 2015;27:677–81. Liu X, et al. Clinical predictors of long-term success in ultrasound-guided high-intensity focused ultrasound ablation treatment for adenomyosis: a retrospective study. Medicine. 2016;95(3):e2443. Rabinovici J, et al. Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod. 2006;21(5):1255–9. Zhou C. High-intensity focused ultrasound ablation technology to treat the efficacy of uterine adenomyosis and pregnancy outcome. Zunyi: Zunyi Medical College; 2017. p. 1-z. Chen J, et al. Safety of ultrasound-guided ultrasound ablation for uterine fibroids and adenomyosis: a review of 9988 cases. Ultrason Sonochem. 2015;27:671–6. Feng Y, et al. Safety of ultrasound-guided high-intensity focused ultrasound ablation for diffuse adenomyosis: a retrospective cohort study. Ultrason Sonochem. 2017;36:139–45. Khalilzadeh O, et al. Proposal of a new adverse event classification by the society of interventional radiology standards of practice committee. J Vasc Interv Radiol. 2017;28(10):1432–1437. e3. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. About this chapter Cite this chapter Ye, M. (2021). The Therapeutic Effect of HIFU on Adenomyosis. In: Xue, M., Leng, J., Wong, F. (eds) Adenomyosis. Springer, Singapore. https://doi.org/10.1007/978-981-33-4095-4_15 Download citation DOI: https://doi.org/10.1007/978-981-33-4095-4_15 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-33-4094-7 Online ISBN: 978-981-33-4095-4 eBook Packages: MedicineMedicine (R0)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK