{"paper_id":"3578ae7d-3626-4c76-b91c-99f114d145af","body_text":"Abstract\nAbout 70% of patients with adenomyosis have clinical symptoms, including pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, and menstrual abnormalities as increased menstrual bleeding and prolonged menstrual period. It may also produce pressure symptoms due to the uterine enlargement caused by adenomyosis [1]. A large number of studies have also confirmed that adenomyosis can affect women’s pregnancy and fertility, including subfertility and even infertility, as well as affect adverse obstetric outcomes, such as miscarriage, premature delivery, premature rupture of membranes, and also affect the treatment outcomes of in vitro fertilization [2–5]. These clinical symptoms are often the reasons for the patient’s consultation visits. When evaluating the treatment effectiveness of adenomyosis, on the one hand, the safety of the method must be considered. On the other hand, the improvement of the above symptoms and obstetrics outcomes should also be evaluated. As a new treatment method for adenomyosis, we should consider HIFU, not only its non-invasive approach but also its safety and effectiveness. Here we summarize the efficacy of HIFU treatment for adenomyosis in this chapter.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nGordts S, Grimbizis G, Campo R. Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertil Steril. 2018;109(3):380–388. e1.\nMatalliotakis IM, Katsikis IK, Panidis DK. Adenomyosis: what is the impact on fertility? Curr Opin Obstet Gynecol. 2005;17(3):261–4.\nMaheshwari A, et al. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update. 2012;18(4):374–92.\nJuang CM, et al. Adenomyosis and risk of preterm delivery. BJOG Int J Obstet Gynaecol. 2007;114(2):165–9.\nYounes G, Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril. 2017;108(3):483–490.e3.\nYang Z, et al. Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis. Fertil Steril. 2009;91(6):2338–43.\nYoon S-W, et al. Successful use of magnetic resonance–guided focused ultrasound surgery to relieve symptoms in a patient with symptomatic focal adenomyosis. Fertil Steril. 2008;90(5):2018. e13–5.\nZhou M, et al. Ultrasound-guided high-intensity focused ultrasound ablation for adenomyosis: the clinical experience of a single center. Fertil Steril. 2011;95(3):900–5.\nLee J-S, et al. Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: a single center experience from the Republic of Korea. Ultrason Sonochem. 2015;27:682–7.\nMarques ALS, et al. Is high-intensity focused ultrasound effective for the treatment of adenomyosis? A systematic review and meta-analysis. J Minim Invasive Gynecol. 2020;27(2):332–43.\nShui L, et al. High-intensity focused ultrasound (HIFU) for adenomyosis: two-year follow-up results. Ultrason Sonochem. 2015;27:677–81.\nLiu X, et al. Clinical predictors of long-term success in ultrasound-guided high-intensity focused ultrasound ablation treatment for adenomyosis: a retrospective study. Medicine. 2016;95(3):e2443.\nRabinovici J, et al. Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod. 2006;21(5):1255–9.\nZhou C. High-intensity focused ultrasound ablation technology to treat the efficacy of uterine adenomyosis and pregnancy outcome. Zunyi: Zunyi Medical College; 2017. p. 1-z.\nChen J, et al. Safety of ultrasound-guided ultrasound ablation for uterine fibroids and adenomyosis: a review of 9988 cases. Ultrason Sonochem. 2015;27:671–6.\nFeng Y, et al. Safety of ultrasound-guided high-intensity focused ultrasound ablation for diffuse adenomyosis: a retrospective cohort study. Ultrason Sonochem. 2017;36:139–45.\nKhalilzadeh O, et al. Proposal of a new adverse event classification by the society of interventional radiology standards of practice committee. J Vasc Interv Radiol. 2017;28(10):1432–1437. e3.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.\nAbout this chapter\nCite this chapter\nYe, M. (2021). The Therapeutic Effect of HIFU on Adenomyosis. In: Xue, M., Leng, J., Wong, F. (eds) Adenomyosis. Springer, Singapore. https://doi.org/10.1007/978-981-33-4095-4_15\nDownload citation\nDOI: https://doi.org/10.1007/978-981-33-4095-4_15\nPublished:\nPublisher Name: Springer, Singapore\nPrint ISBN: 978-981-33-4094-7\nOnline ISBN: 978-981-33-4095-4\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}