Ultrasound-guided high-intensity focused ultrasound ablation for adenomyosis: the clinical experience of a single center

Zhou M, Min Zhou, Jinyun Chen, Chen JY, Jin-Yun Chen, Liangdan Tang, Liang-Dan Tang, Tang LD, Chen WZ, Wen-Zhi Chen, Wenzhi Chen, Zhi-Biao Wang, Zhibiao Wang, Wang ZB
Fertility and sterility · 2010 · vol. 95(3) , pp. 900–905 · doi:10.1016/j.fertnstert.2010.10.020 · PMID:21067723 · W2073145938
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This paper reports on the clinical experience of a single center utilizing ultrasound-guided high-intensity focused ultrasound ablation for treating adenomyosis.

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Abstract

ObjectiveTo assess the midterm outcomes after ultrasound-guided high-intensity focused ultrasound (HIFU) ablation in treatment of patients with symptomatic adenomyosis.DesignA prospective clinical trial.SettingUniversity teaching hospital.Patient(s)Seventy-eight patients with symptomatic adenomyosis.Intervention(s)A single treatment session of ultrasound-guided HIFU ablation for adenomyosis.Main outcome measure(s)Dysmenorrhea and menorrhagia scores and the incidence of complications.Result(s)In all 78 patients, 84.6% tolerated the treatment procedure well with pain scores between 0 and 4. Treatment was terminated in only one patient because of increased blood pressure persistently. Sixty-nine patients have finished at least an 18-month follow-up; the mean follow-up time was 24.2 months. Nonperfused regions in lesions were observed in 60 (87.0%) patients on the enhanced magnetic resonance imaging scans. Scores for menorrhea and dysmenorrhea decreased. Clinical effectiveness of the treatment was observed in 62 women (89.9%) with varying degrees of symptomatic relief of dysmenorrhea. Eight patients had relapses. Twenty-two patients (28.6%) had 27 complications. Of these, four had two or more complications. Twenty-three events (85.1%) did not need medical intervention (Society of Interventional Radiology class A). No serious complications including death or major permanent injuries were observed.Conclusion(s)Ultrasound-guided HIFU ablation may be a safe and effective noninvasive alternative in the treatment of symptomatic adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometriosis High-Intensity Focused Ultrasound Ablation Adult Endometriosis Endometriosis Female Follow-Up Studies High-Intensity Focused Ultrasound Ablation High-Intensity Focused Ultrasound Ablation Humans Magnetic Resonance Imaging Middle Aged Patient Satisfaction Postoperative Complications Prospective Studies Recurrence Treatment Outcome Ultrasonography

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