Treatment options and reproductive outcome for adenomyosis-associated infertility

Ilaria Soave, Soave I, Jean‐Marie Wenger, Wenger JM, Jean-Marie Wenger, Nicola Pluchino, Roberto Marci, Marci R
Current medical research and opinion · 2017 · vol. 34(5) , pp. 839–849 · doi:10.1080/03007995.2017.1393404 · PMID:29046066 · W2767178490
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This review examined treatments for adenomyosis-associated infertility, finding limited data on efficacy but acknowledging adenomyosis negatively impacts fertility.

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Abstract

PURPOSE: Adenomyosis is a benign gynecological disease mostly diagnosed in the forth and fifth decades. The recent improvement of the diagnostic tools and a better understanding of the pathology allowed clinicians to postulate a possible relationship between adenomyosis and infertility and to diagnose it in younger asymptomatic women during infertility work-up. Purpose of this article is to review the different theories regarding the possible correlation between adenomyosis and infertility and to discuss the treatment options and the final reproductive outcome after the treatment. MATERIALS AND METHODS: We search Pubmed for articles published in the English language with the use of the following MeSH search terms: "adenomyosis" combined with "treatment" and "fertility outcome" with the restriction to the human species. A manual search of review articles and cross-references completed the search. All selected articles were assessed for study design, patients characteristic, diagnosis of adenomyosis, type of treatment, post-treatment rates of conception, full-term pregnancy and completeness of information of the data sets. RESULTS: Limited data are available concerning the efficacy of the different treatment options of adenomyosis on fertility outcome and the only ones published are retrospective evaluations or small case series. CONCLUSIONS: Adenomyosis represents a common gynecological disorder with a negative impact on fertility. However, it remains challenging to establish if adenomyosis is the only cause of the infertility or not, because patients, in both case and control groups, may be affected by concomitant endometriosis. Further studies are required to determine the reason of implantation failure in women with adenomyosis and the impact of adenomyosis on infertile women with or without endometriosis.

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Condition tags

endometriosisadenomyosisinfertility

MeSH descriptors

Adenomyosis Infertility, Female Infertility, Female Infertility, Female Adenomyosis Female Humans Pregnancy Pregnancy Retrospective Studies Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (31)

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europepmc
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License: CC0 · commercial use OK