Adenomyosis and endometriosis in the California Teachers Study

Claire Templeman, Templeman C, Marshall SF, Sarah F Marshall, Giske Ursin, Ursin G, Horn-Ross PL, Pamela L. Horn‐Ross, Pamela L Horn-Ross, Clarke CA, Christina A Clarke, Mark S. Allen, Mark Allen, Allen M, Dennis Deapen, Deapen D, Ziogas A, Argyrios Ziogas, Reynolds P, Peggy Reynolds, Rosemary D. Cress, Rosemary Cress, Cress R, Anton-Culver H, Hoda Anton‐Culver, Hoda Anton-Culver, Dee W. West, Dee West, West D, Ronald K Ross, Ross RK, Bernstein L, Leslie Bernstein
Fertility and sterility · 2007 · vol. 90(2) , pp. 415–424 · doi:10.1016/j.fertnstert.2007.06.027 · PMID:17919609 · PMC2813675 · W1977546588
article OA: green CC0 ⤵ 109 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the association between various factors and the incidence of adenomyosis and endometriosis among participants in the California Teachers Study.

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Abstract

ObjectiveTo evaluate the reproductive and lifestyle correlates of a surgically confirmed diagnosis of endometriosis or adenomyosis in a large prospective cohort.DesignCollection of surgical diagnoses of endometriosis and adenomyosis during follow-up of women with no prior history of endometriosis and no prior surgery for adenomyosis.SettingThe California Teachers Study (CTS), an ongoing prospective study of female teachers and school administrators established from the rolls of the California State Teachers Retirement System.Patient(s)Women with surgical diagnoses of endometriosis and adenomyosis were identified from California statewide hospital patient discharge records for CTS cohort members with an intact uterus and no prior history of endometriosis. Women with an incident surgical diagnosis of endometriosis (n = 229) or adenomyosis (n = 961) were compared with disease-free women in the same age range (for endometriosis, n = 43,493; for adenomyosis, n = 79,495).Intervention(s)None.Main outcome measure(s)Multivariable logistic regression methods were used to calculate prevalence odds ratios and associated 95% confidence intervals for the associations between self-reported menstrual and reproductive characteristics and either endometriosis or adenomyosis.Result(s)Women surgically diagnosed with endometriosis were younger than those surgically diagnosed with adenomyosis. Factors statistically significantly associated with endometriosis were having a mother or sister with endometriosis and nulligravidity. Factors statistically significantly associated with adenomyosis were increasing parity, early menarche (<or=10 years of age), and short menstrual cycles (<or=24 days in length). Obese women also were more likely to have a surgical diagnosis of adenomyosis.Conclusion(s)These observations provide the first epidemiologic profile of women with a surgical diagnosis of adenomyosis and indicate that this profile differs from that of women with a surgical diagnosis of endometriosis. Our results also suggest that adenomyosis but not endometriosis is associated with increased endogenous exposure to estrogen.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Adolescent Adult Aged California California Child Cohort Studies Endometriosis Female Humans Menarche Menstrual Cycle Middle Aged Multivariate Analysis Prevalence Prospective Studies Risk Factors

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References (23)

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