Insights on Adenomyosis Development

Silvia Vannuccini, Sara Clemenza
In: Endometriosis and Adenomyosis · 2022 · pp. 423–440 · doi:10.1007/978-3-030-97236-3_31 · W4285308662
book-chapter OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Adenomyosis involves endometrial tissue within the myometrium, with proposed causes including endometrial invagination or stem cell metaplasia, driven by estrogen dependence and progesterone resistance.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper/chapter reviews what is known about adenomyosis development, describing the condition’s defining features and the shift from an older view (mostly older multiparous women diagnosed after hysterectomy) to more frequent identification in younger women using transvaginal ultrasound and MRI. It summarizes major proposed pathogenic theories (endometrial basalis invagination into the myometrium versus metaplasia of Müllerian remnants or differentiation of adult stem cells) and highlights linked mechanisms including hormonal dysregulation (estrogen dependence and progesterone resistance), inflammation, immune abnormalities, altered cell proliferation/migration/invasion, fibrosis, and neuroangiogenesis. A key caveat is that the pathogenesis remains unclear, with mechanisms and origins still under debate. Relevance to endometriosis: the paper explicitly addresses the mechanistic context of endometriosis and adenomyosis association via shared themes such as tissue injury/repair and related immune/inflammatory pathways, though its main focus is adenomyosis development and pathogenesis. This paper is centrally about adenomyosis — it reviews theories and mechanisms of adenomyosis development.

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adenomyosis

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License: CC0 · commercial use OK