Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis
article
OA: closed
CC0
⤵ 21 in-corpus citations
Limited metadata. Only one source feed has indexed
this record so far — no abstract, full text, or open-access copy is
available through Endo Lab. The
publisher's page (linked below)
is the canonical location for the actual content. If you have institutional
access, use "Find at my library".
AI-generated summary
This study investigated the effects of dienogest on human adenomyosis, finding that it reduced cell proliferation, nerve growth factor expression, and nerve fiber density in excised tissue.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (19)
- Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist via openalex
- Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells via openalex
- Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system via openalex
- Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture via openalex
- Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis via openalex
- Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model via openalex
- Effects of Dienogest on Surgically Induced Endometriosis in Rats after Repeated Oral Administration via openalex
- Effects of the levonorgestrel-releasing intrauterine system on cell proliferation, Fas expression and steroid receptors in endometriosis lesions and normal endometrium via openalex
- Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study via openalex
- Exploratory study of pre‐surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts via openalex
- Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1 via openalex
- Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification via openalex
- Human Adenomyosis Endometrium Stromal Cells Secreting More Nerve Growth Factor via openalex
- W2091792970 via openalex
- W2110802986 via openalex
- W2046867627 via openalex
- W2038354928 via openalex
- W2033363713 via openalex
- W1925466818 via openalex
Cited by (21)
- Medical treatment for adenomyosis: long term use of progestins 2025
- Comparative Study of 0.5 mg Dienogest Tablets (1 mg/Day) and Continuous Low-Dose Estrogen/Progestin for Dysmenorrhea: A Retrospective Analysis—Influence of Bleeding-Related Factors Such as Endometrial Polyps, Uterine Fibroids, and Adenomyosis 2025
- The Impact of Uterine Disorders on Embryo Implantation and Early Survival: From Molecular Insights to Clinical Evidence 2025
- Metabolic changes in myometrium associated with adenomyosis revealed by liquid chromatography-tandem mass spectrometry-based high-throughput targeted lipid quantitative profiling 2025
- Adenomyosis: Unravelling the causes and exploring treatment strategies among patients seeking conception 2025
- Influence of endometrial nerve fibers and hormones on pain in women with endometriosis 2025
- Clinical efficacy of dienogest against endometriomas with a maximum diameter of ≥4 cm 2024
- Compare the Efficacy of Dienogest and the Levonorgestrel Intrauterine System in Women with Adenomyosis 2023
- Investigation of the 12-month efficacy and safety of low-dose mifepristone in the treatment of painful adenomyosis 2022
- Insights on Adenomyosis Development 2022
- Clinical Efficacy of Dienogest and Levonorgestrel-Releasing Intrauterine System in the Treatment of Adenomyosis 2022
- Medical Treatment of Adenomyosis 2022
- Segmented in vitro fertilization and frozen embryo transfer in dienogest-treated patient with adenomyosis: A case report and lierature review 2022
- Physiopathologie de l’adénomyose : une énigme non résolue 2021
- Empirical and long-term therapy for endometriosis-associated pelvic pain 2021
- Systematic review and Meta-analysis of efficacy and safety of dienogest in treatment of endometriosis 2021
- Adenomyosis: clinical aspects, impact on fertility and pregnancy outcome 2020
- Assessment of the results of comprehensive examination in patients with adenomyosis 2019
- Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations 2019
- Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis 2018
- Minimally invasive treatment of adenomyosis 2018
Source provenance
- europepmc
- last seen: 2026-06-18T06:15:08.409253+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:20:43.714878+00:00
License: CC0
· commercial use OK