Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis

Takeuchi A, Arisa Takeuchi, Kaori Koga, Mariko Miyashita, Mariko Miyashita‐Ishiwata, Miyashita M, Tomoko Makabe, Makabe T, Fusako Sue, Sue F, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Fujii T, Tomoyuki Fujii, Osuga Y, Yutaka Osuga
European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 207 , pp. 157–161 · doi:10.1016/j.ejogrb.2016.10.053 · PMID:27865118 · W2556237230
article OA: closed CC0 ⤵ 21 in-corpus citations
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This study investigated the effects of dienogest on human adenomyosis, finding that it reduced cell proliferation, nerve growth factor expression, and nerve fiber density in excised tissue.

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Abstract

ObjectivesTo evaluate the in vivo effect of dienogest on proliferation, apoptosis, aromatase expression, vascular density, nerve growth factor (NGF) expression and nerve fiber density in human adenomyosis tissue.Study designTwelve women who underwent hysterectomy for adenomyosis were enrolled. Six patients received dienogest treatment prior to hysterectomy (dienogest group), and age-matched six patients who had not received any hormonal treatment for ≥3 months before surgery (control group). Cell proliferation, vascular and nerve fiber density in adenomyosis tissue were evaluated by staining for Ki67, von Willebrand factor and PGP9.5, respectively. Apoptosis was detected using the TUNEL assay. The expression aromatase and NGF were evaluated by staining for corresponding antibodies.ResultsThe proportion of Ki67 positive epithelial cells was significantly lower in samples from dienogest-treated patients in comparison with controls (p<0.05). The density of blood vessels in adenomyosis was marginally lower in the dienogest group in comparison with controls but statistical significance was not reached (p=0.07). The intensity of NGF expression and the density of nerve fibers were significantly lower in the dienogest group compared with controls (p<0.05 for both).ConclusionThis study demonstrates that adenomyosis, taken from patients treated with dienogest, shows remarkable histological features, such as reductions in proliferation, NGF expression and nerve fiber density. These findings indicate the impact of dienogest on local histological events, and explains its therapeutic effect on adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Antineoplastic Agents, Hormonal Down-Regulation Endometrium Myometrium Nandrolone Nerve Growth Factor Adenomyosis Adenomyosis Adenomyosis Adenomyosis Administration, Oral Adult Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Apoptosis Apoptosis Cell Proliferation Combined Modality Therapy

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