Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system

MeSH descriptors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

• Advances in the management of endometriosis: an update for clinicians via openalex
• Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: New questions—old answers? via openalex
• Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression via openalex
• Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex
• Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
• Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex
• Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex
• DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection via openalex
• Endometriosis via openalex
• Expression of Inducible Microsomal Prostaglandin E Synthase in Local Lesions of Endometriosis Patients via openalex
• High-dose pilot study with the novel progestogen dienogestin patients with endometriosis via openalex
• Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis via openalex
• Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? via openalex
• Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex
• Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients via openalex
• The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro via openalex
• The role of progestins in treating the pain of endometriosis via openalex
• Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor via openalex
• W6676336829 via openalex
• W1980087584 via openalex
• W1989696800 via openalex
• W1991538165 via openalex
• W2001963326 via openalex
• W2011025558 via openalex
• W2022658482 via openalex
• W2039464272 via openalex
• W2044204905 via openalex
• W2060736868 via openalex
• W2068397002 via openalex
• W2075751134 via openalex
• W2101249156 via openalex
• W2109525253 via openalex
• W2110187085 via openalex
• W2121754708 via openalex
• W4255996882 via openalex
• W1606655713 via openalex

Cited by (50)

• WITHDRAWN: Effects of Deinorgestrel Treatment of Endometriosis on Ovarian Function, Inflammatory Factors, and Pregnancy Rate in Patients 2025
• Comparative Study of 0.5 mg Dienogest Tablets (1 mg/Day) and Continuous Low-Dose Estrogen/Progestin for Dysmenorrhea: A Retrospective Analysis—Influence of Bleeding-Related Factors Such as Endometrial Polyps, Uterine Fibroids, and Adenomyosis 2025
• ENDOMETRİOZ 2023
• Dienogest versus norethisterone acetate in management of endometrial hyperplasia without atypia 2023
• The issues of endometriosis hormonal treatment in reproductive age women 2022
• Efficacy of Low-Dose Estrogen–Progestins and Progestins in Japanese Women with Dysmenorrhea: A Systematic Review and Network Meta-analysis 2022
• Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism 2022
• Segmented in vitro fertilization and frozen embryo transfer in dienogest-treated patient with adenomyosis: A case report and lierature review 2022
• Randomized Study on the Effectiveness of Nomegestrol Acetate Plus 17β-Estradiol Oral Contraceptive vs Dienogest Oral Pill in Women with Endometriosis‑Associated Chronic Pelvic Pain 2022
• Germany Endometriosis Pattern Changes; Prevalence and Therapy over 2010 and 2019 Years: A Retrospective Cross-Sectional Study. 2022
• Endometriosis - Recent Advances, New Perspectives and Treatments 2021
• Collagen I triggers directional migration, invasion and matrix remodeling of stroma cells in a 3D spheroid model of endometriosis 2021
• Role of estrogen and estrogen-related factors in endometriosis 2021
• Potential Therapeutic Options and Perspectives for Alleviation of Endometrial Estrogen Dominance and Progesterone Resistance in Endometriosis 2021
• A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion - 2020
• The scar constituent Collagen I triggers coordinated collective migration and invasion in a 3D spheroid model of early endometriotic lesions 2020
• Dienogest exerts its anti-endometriotic effect throughthe direct suppression of matrix metallopeptidases 2020
• Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure 2020
• Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology 2020
• New treatment strategy for endometriosis using progestin-primed ovarian stimulation with dienogest: A prospective cohort study, comparison of dienogest versus dydrogesterone 2020
• Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? 2019
• Comparison of dienogest effects upon 3,3′–diindolylmethane supplementation in models of endometriosis and clinical cases 2018
• Aromatase as a target for treating endometriosis 2018
• Dysmenorrhea, endometriosis, adenomyosis: clinical and pathogenetic relationships 2018
• The efficacy of selective cyclooxygenase 2 inhibitors in the treatment of genital endometriosis 2018
• Impact of a Chinese Medicinal Formula, Xiao Liu Fang, on the “3A” Ability of Endometrial Stromal Cells in Patients with Endometriosis 2018
• Investigational Medical Therapies for Endometriosis: Current Data and Future Trends 2017
• Evaluation of Dienogest Treatment Efficacy in Patients with Endometriosis 2017
• The Efficacy of Dienogest in the Treatment of Simple Endometrial Hyperplasia without Atypia 2017
• Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines 2017
• Progesterone resistance in endometriosis: origins, consequences and interventions 2017
• Ileal endometriosis with a recurrence of intestinal obstruction during menstruation 2016
• Preconceptional use of combination of estradiol valerate and dienogest for contraception and treatment of heavy menstrual bleeding in women with chronic endometritis 2016
• Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis 2016
• Development of an endometrial inspired biomaterial 2016
• Dienogest reduces HSD17β1 expression and activity in endometriosis 2015
• Does dienogest influence the inflammatory response of endometriotic cells? A systematic review 2015
• Dienogest improves human leucocyte antigen-DR underexpression and reduces tumour necrosis factor-α production in peritoneal fluid cells from women with endometriosis 2014
• Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells 2014
• Roles of Prostaglandin E2 in Endometriosis 2014
• Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-α or interleukin-1β 2013
• Role of prostaglandin E2 in the experimental L-carnitine-induced endometriosis-like inflammatory model 2012
• Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture 2012
• The use of an oral contraceptive containing estradiol valerate and dienogest before office operative hysteroscopy: a feasibility study 2012
• Stretch magnitude- and frequency-dependent cyclooxygenase 2 and prostaglandin E2 up-regulation in human endometrial stromal cells: Possible implications in endometriosis 2012
• Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review) 2012
• Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line 2012
• Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis 2012
• Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells 2011
• The role of prostaglandin E ₂ in endometriosis 2011

Source provenance

europepmc

last seen: 2026-06-04T01:30:01.192114+00:00

openalex

last seen: 2026-06-10T17:14:06.276822+00:00

pubmed

last seen: 2026-05-13T22:17:00.782903+00:00