High-dose pilot study with the novel progestogen dienogestin patients with endometriosis
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High-dose dienogest (20 mg/day) effectively treated endometriosis, including stage IV, with a favorable side-effect profile compared to other progestin therapies.
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Abstract
High-dose dienogest (20 mg/day) was used for the treatment of endometriosis in women aged 18-52 years after laparoscopic and histological diagnosis of endometriosis and staging according to the revised American Fertility Society criteria. Treatment efficacy was analyzed objectively by second-look laparoscopy, and serum hormone measurements and evaluation of endometriosis-related symptoms were performed done and side-effects recorded. Compared with other high-dose progestin therapies, treatment with dienogest was shown to be effective even in stage IV endometriosis. The side-effect profile of the high-dose dienogest treatment appears to be highly favorable compared with other treatments. Neither the menopausal symptoms caused by therapy with gonadotropin-releasing hormone agonists nor the adverse androgen-related effects induced by danazol were observed. Therefore, long-term high-dose dienogest therapy can be recommended particularly for women with progressive endometriosis.
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- Adenosine deaminase family acting on RNA 1 may be a de novo target on endometriosis 2023
- A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion - 2020
- CLINICAL CASE OF SUCCESSFUL TREATMENT OF INFERTILITY IN A PATIENT WITH FAILURE IVF RESULTS IN ANAMNESIS 2020
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- Dienogest Therapy as a Treatment for Catamenial Pneumothorax: Case Report and Review of Hormonal Options 2017
- The effect of genistein on TGF-β signal, dysregulation of apoptosis, cyclooxygenase-2 pathway, and NF-kB pathway in mice peritoneum of endometriosis model 2017
- Ureteral endometriosis: A systematic literature review 2017
- Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma 2017
- Oral and depot progestin therapy for endometriosis: towards a personalized medicine 2017
- The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment 2016
- From the history of studies of endometriosis to current treatments 2016
- The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment 2016
- The effeciency of IVF protocols in patients with moderate to severe endometriosis after adjuvant therapy 2015
- Hormonal Treatment for Severe Hydronephrosis Caused by Bladder Endometriosis 2014
- Dienogest in the treatment of endometriosis 2014
- Ureteral Endometriosis: Proposal for a Diagnostic and Therapeutic Algorithm with a Review of the Literature 2013
- Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture 2012
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- Sequential Management with Gonadotropin-Releasing Hormone Agonist and Dienogest of Endometriosis-Associated Uterine Myoma and Adenomyosis 2012
- The use of an oral contraceptive containing estradiol valerate and dienogest before office operative hysteroscopy: a feasibility study 2012
- Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women 2012
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- Why use of dienogest for the first contraceptive pill with estradiol? 2010
- Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system 2010
- Dienogest 2010
- Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis 2010
- Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study 2010
- Dienogest: an oral progestogen for the treatment of endometriosis 2010
- Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression 2009
- A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis 2009
- Dienogest and the breast 2009
- Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells 2007
- The value of two-step operative laparoscopy with interval pituitary suppression in the treatment of infertility caused by severe endometriosis 2007
- Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile 2007
- Emerging drugs in endometriosis 2006
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