MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE
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Oral medroxyprogesterone acetate (MPA) at 30 mg daily for 90 days improved or caused remission of endometriosis in all 35 women, with 12 of 26 infertile patients becoming pregnant.
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Abstract
Efficacy of oral medroxyprogesterone acetate (MPA) was assessed in 35 women with an established diagnosis of endometriosis (33 pelvic and 2 abdominal). MPA was given in a dosage of 30 mg daily for 90 days. Results indicated improvement or remission in all cases, even though breakthrough bleeding occurred in 8. Twenty-six were treated for associated infertility. Twelve of these became pregnant following treatment. Pregnancy rate in those women whose husbands were fertile was 90%. Side effects included spotting and breakthrough bleeding. The patients usually remained amenorrheic and anovulatory while receiving MPA. Posttreatment resumption of ovulation was prompt. The findings indicate that oral MPA is a useful therapeutic agent in the management of minimal to moderate endometriosis, particularly when it is associated with infertility.
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- Die Wirkung von hCG auf die Dezidualisierung ektoper endometrialer Läsionen als therapeutischer Ansatz zur Behandlung der Endometriose 2014
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- Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review) 2012
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- Current pharmacotherapy for endometriosis 2010
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- Endometriosis: Treatment Strategies 2003
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- Endometriosis: current concepts and therapy 2002
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- Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis 2001
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- UPDATE ON THE MEDICAL TREATMENT OF ENDOMETRIOSIS 2000
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- Dienogest, a synthetic steroid, suppresses both embryonic and tumor-cell-induced angiogenesis 1999
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- Effects of dienogest (a synthetic steroid) on coagulation, fibrinolysis, and platelet aggregation in female monkeys 1998
- Progestins for symptomatic endometriosis: a critical analysis of the evidence 1997
- Long-term follow-up on the treatment of endometriosis with the GnRH-agonist buserelinacetate Long-term follow-up data (up to 98 months) of 42 patients with endometriosis who were treated with GnRH-agonist buserelinacetate (Suprecur®), were evaluated in respect of recurrence of pain symptoms and pregnancy outcome 1997
- Endometriosis: An Enigmatic Disease 1996
- Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis 1996
- Pain recurrence: A quality of life issue in endometriosis 1995
- 9 Endometriosis: Medical therapy 1993
- Endometriosis in the adolescent and teenage female 1993
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- 7 Endometriosis and pelvic pain 1993
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- Endometriosis—the role of medroxyprogesterone acetate 1992
- Hormonal regulation of endometriotic cell growth in primary cell culture system 1992
- Hormonal regulation of the cell growth in an endometriotic cell culture system 1992
- Gestogens and anti-gestogens as treatment of endometriosis 1991
- Medical treatment of mild endometriosis associated with infertility 1991
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