Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills

Robert F Casper

doi:10.1016/j.fertnstert.2017.01.003

Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills

Robert F Casper

Fertility and sterility · 2017 · vol. 107(3) , pp. 533–536 · doi:10.1016/j.fertnstert.2017.01.003 · PMID:28162779 · W2583357828

review OA: closed CC0 ⤵ 137 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that progestin-only pills may be a more effective first-line treatment option for endometriosis compared to combined estrogen-progestin contraceptive pills.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Contraceptives, Oral, Combined Contraceptives, Oral, Hormonal Endometriosis Endometrium Nandrolone Norethindrone Pelvic Pain Progestins Administration, Oral Contraceptives, Oral, Combined Contraceptives, Oral, Combined Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female

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References (45)

17β-Hydroxysteroid Dehydrogenase-2 Deficiency and Progesterone Resistance in Endometriosis via openalex
Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor- by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions via openalex
Dienogest, a synthetic steroid, suppresses both embryonic and tumor-cell-induced angiogenesis via openalex
Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex
Does Response to Hormonal Therapy Predict Presence or Absence of Endometriosis? via openalex
Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model via openalex
Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex
Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats via openalex
Endometriosis: Diagnosis and Management via openalex
Endometriosis: Role of Ovarian Steroids in Initiation, Maintenance, and Suppression via openalex
Estrogen-progestins and progestins for the management of endometriosis via openalex
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis via openalex
Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata via openalex
Female Perspectives on Endometriosis: Findings from the Uterine Bleeding and Pain Women'S Research Study via openalex
Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex
MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex
Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis: a before and after study via openalex
Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis via openalex
Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex
Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
Practice Bulletin No. 114: Management of Endometriosis via openalex
Progestagens and anti-progestagens for pain associated with endometriosis via openalex
Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex
Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model via openalex
Treatment of pelvic pain associated with endometriosis: a committee opinion via openalex
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W2009670845 via openalex
W2000899261 via openalex
W1968456293 via openalex
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Cited by (50)

Source provenance

europepmc: last seen: 2026-06-11T06:19:48.454388+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:20:37.704673+00:00
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License: CC0 · commercial use OK

[1] 17β-Hydroxysteroid Dehydrogenase-2 Deficiency and Progesterone Resistance in Endometriosis via openalex

[2] Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor- by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions via openalex

[3] Dienogest, a synthetic steroid, suppresses both embryonic and tumor-cell-induced angiogenesis via openalex

[4] Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex

[5] Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex

[6] Does Response to Hormonal Therapy Predict Presence or Absence of Endometriosis? via openalex

[7] Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model via openalex

[8] Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex

[9] Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats via openalex

[10] Endometriosis: Diagnosis and Management via openalex

[11] Endometriosis: Role of Ovarian Steroids in Initiation, Maintenance, and Suppression via openalex

[12] Estrogen-progestins and progestins for the management of endometriosis via openalex

[13] Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis via openalex

[14] Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata via openalex

[15] Female Perspectives on Endometriosis: Findings from the Uterine Bleeding and Pain Women'S Research Study via openalex

[16] Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex

[17] MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex

[18] Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis: a before and after study via openalex

[19] Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis via openalex

[20] Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex

[21] Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex

[22] Practice Bulletin No. 114: Management of Endometriosis via openalex

[23] Progestagens and anti-progestagens for pain associated with endometriosis via openalex

[24] Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex

[25] Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model via openalex

[26] Treatment of pelvic pain associated with endometriosis: a committee opinion via openalex

[27] W2101417341 via openalex

[28] W2152628855 via openalex

[29] W2154377312 via openalex

[30] W2163315477 via openalex

[31] W2170973793 via openalex

[32] W2070651949 via openalex

[33] W2228635764 via openalex

[34] W2051636067 via openalex

[35] W2272521481 via openalex

[36] W2021687464 via openalex

[37] W2009670845 via openalex

[38] W2000899261 via openalex

[39] W1968456293 via openalex

[40] W6607311167 via openalex

[41] W6638359506 via openalex

[42] W6658221620 via openalex

[43] W2134481084 via openalex

[44] W6669579114 via openalex

[45] W2145176599 via openalex