Advances in the diagnosis and management of endometriosis: A comprehensive review

Yingying Chen; Shanza Waseem; S Waseem; Li Luo

doi:10.1016/j.prp.2025.155813

Advances in the diagnosis and management of endometriosis: A comprehensive review

Yingying Chen, Shanza Waseem, S Waseem, Li Luo

Pathology, research and practice · 2025 · vol. 266 , pp. 155813 · doi:10.1016/j.prp.2025.155813 · PMID:39808858 · W4406166156

review OA: closed CC0 ⤵ 11 in-corpus citations

View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review compiles recent advancements in diagnosing and managing endometriosis, covering diagnostic tools and therapeutic strategies.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a prevalent gynecological condition characterized by the presence of endometrial-like tissue outside the uterus, leading to chronic pelvic pain and infertility. This review aims to shed light on the latest advancements in diagnosing and managing endometriosis. It offers insight into the condition's pathogenesis, clinical symptoms, diagnostic techniques, and available treatment approaches. Furthermore, the article emphasizes innovative technologies and novel therapeutic strategies that promise to enhance patient outcomes significantly. This review aspires to empower clinicians to deliver the highest quality care to their patients affected by this challenging condition by consolidating the current understanding of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Advances in Treatment Options of Endometriosis via openalex
A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study via openalex
Analysis of the levonorgestrel-releasing intrauterine system in women with endometriosis via openalex
An update on the biological markers of endometriosis via openalex
A prospective cohort study of endometriosis and subsequent risk of infertility via openalex
Association between chronic pelvic pain symptoms and the presence of endometriosis via openalex
Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients via openalex
A stepped-care approach to symptomatic endometriosis management: a participatory research initiative via openalex
Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives via openalex
Biomarkers in endometriosis: challenges and opportunities via openalex
Biomarkers of endometriosis via openalex
Blood biomarkers for the non-invasive diagnosis of endometriosis via openalex
Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications via openalex
Classification algorithm of patients with endometriosis: Proposal for tailored management via openalex
Clinical Management of Endometriosis via openalex
Clinical use of artificial intelligence in endometriosis: a scoping review via openalex
Clinical use of endovenous indocyanine green during rectosigmoid segmental resection for endometriosis via openalex
Coelomic Metaplasia Theory of Endometriosis: Evidence from in vivo Studies and an in vitro Experimental Model via openalex
[Conservative treatment of endometriosis]. via openalex
Correction to: “The Sword in the Stone”: radical excision of deep infiltrating endometriosis with bowel shaving—a single‑centre experience on 703 consecutive patients via openalex
Correlation between endometriosis and pelvic pain via openalex
CRITERIA THAT INDICATE ENDOMETRIOSIS IS THE CAUSE OF CHRONIC PELVIC PAIN via openalex
Current and Emerging Therapeutics for the Management of Endometriosis via openalex
Current Role of Modern Chromatography with Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy in the Investigation of Biomarkers of Endometriosis via openalex
Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review via openalex
Deep Dyspareunia and Sexual Quality of Life in Women With Endometriosis via openalex
Deep pelvic endometriosis: don’t forget round ligaments. Review of anatomy, clinical characteristics, and MR imaging features via openalex
Development and Validation of an Endometriosis Diagnostic Method Based on Serum Biomarkers and Clinical Variables via openalex
Diagnosis and Nursing Intervention of Gynecological Ovarian Endometriosis with Magnetic Resonance Imaging under Artificial Intelligence Algorithm via openalex
Diagnosis of deep endometriosis: clinical examination, ultrasonography, magnetic resonance imaging, and other techniques via openalex
Diagnosis of endometriosis in the 21st century via openalex
Diagnostic accuracy and potential limitations of transvaginal sonography for bladder endometriosis via openalex
Effectiveness of presacral neurectomy in women with severe dysmenorrhea caused by endometriosis who were treated with laparoscopic conservative surgery: A 1-year prospective randomized double-blind controlled trial via openalex
Efficacy and safety of oral gonadotropin-releasing hormone antagonists in moderate-to-severe endometriosis-associated pain: a systematic review and network meta-analysis via openalex
Emerging drugs for endometriosis via openalex
Endometrial biomarkers for the non-invasive diagnosis of endometriosis via openalex
Endometriosis via openalex
Endometriosis via openalex
Endometriosis: A multimodal imaging review via openalex
Endometriosis and Infertility via openalex
Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women via openalex
Endometriosis and infertility: Insights into the causal link and management strategies via openalex
Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options via openalex
Endometriosis. Current issues in diagnosis and medical management. via openalex
Endometriosis: Epidemiology, Diagnosis and Clinical Management via openalex
Endometriosis Pain Management: a Review via openalex
Endometriosis: pathophysiology, diagnosis, and treatment. via openalex
Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium via openalex
EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Evaluation of quality of life in fertile Turkish women with severe endometriosis via openalex
Evidence for the role of multidisciplinary team care in people with pelvic pain and endometriosis: A systematic review via openalex
Extrapelvic Endometriosis: A Systematic Review via openalex
Fertility- and Nerve-sparing Laparoscopic Eradication of Deep Endometriosis with Total Posterior Compartment Peritonectomy: The Kurashiki Method via openalex
Fertility-related considerations in endometriosis via openalex
Fertility sparing double discoid excision of rectosigmoid deep endometriosis under robotic-integrated ultrasound guidance via openalex
Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options via openalex
Going beyond the surface: a mixed-method exploration of infertility-related quality of life of women with endometriosis via openalex
Guidelines for biomarker discovery in endometrium: correcting for menstrual cycle bias reveals new genes associated with uterine disorders via openalex
Hormonal contraception in women with endometriosis: a systematic review via openalex
Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics via openalex
Imaging Modalities for Diagnosis of Deep Pelvic Endometriosis: Comparison between Trans-Vaginal Sonography, Rectal Endoscopy Sonography and Magnetic Resonance Imaging. A Head-to-Head Meta-Analysis via openalex
Imaging modalities for the non-invasive diagnosis of endometriosis via openalex
Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women. via openalex
Introduction via openalex
Laparoscopic conservative surgery for stage IV symptomatic endometriosis: short-term surgical complications via openalex
Laparoscopic Management of Ureteral Endometriosis: The Stanford University Hospital Experience With 96 Consecutive Cases via openalex
Laparoscopic surgery for endometriosis via openalex
Laparoscopic versus laparotomic radical en bloc hysterectomy and colorectal resection for endometriosis via openalex
Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis via openalex
Limitations of transvaginal sonography for the diagnosis of adenomyosis, with histopathological correlation via openalex
Liquid Biopsy in Endometriosis: A Systematic Review via openalex
Magnetic resonance imaging for deep infiltrating endometriosis: current concepts, imaging technique and key findings via openalex
Management of endometriosis from diagnosis to treatment: roadmap for the future via openalex
Medical management of endometriosis via openalex
Medical Management of Endometriosis via openalex
Medical management of endometriosis: a systematic review. via openalex
Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials via openalex
Multi-disciplinary centres/networks of excellence for endometriosis management and research: a proposal via openalex
Multiple nodule removal in multifocal colorectal endometriosis instead of “en bloc” large colorectal resection via openalex
Near-Infrared Imaging with Indocyanine Green for Detection of Endometriosis Lesions (Gre-Endo Trial): A Pilot Study via openalex
New biomarkers in endometriosis via openalex
New developments in the medical treatment of endometriosis via openalex
New Insights in Pathogenesis of Endometriosis via openalex
New Insights into Genetics of Endometriosis—A Comprehensive Literature Review via openalex
New paradigms in the diagnosis and management of endometriosis via openalex
Non-invasive diagnosis of endometriosis: Immunologic and genetic markers via openalex
Non-invasive methods of diagnosis of endometriosis via openalex
Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis via openalex
Novel agents for the medical treatment of endometriosis via openalex
Novel pharmacological therapies for the treatment of endometriosis via openalex
Novel targets for the treatment of endometriosis via openalex
Novel Therapies Targeting Endometriosis via openalex
Occult microscopic endometriosis: undetectable by laparoscopy in normal peritoneum via openalex
Omics-based novel strategies in the diagnosis of endometriosis via openalex
Pain and Quality of Life after Laparoscopic Excision of Endometriosis via openalex
Painful Love: Superficial Dyspareunia and Three Dimensional Transperineal Ultrasound Evaluation of Pelvic Floor Muscle in Women with Endometriosis via openalex
Pain in endometriosis: effectiveness of medical and surgical management via openalex
Pathogenesis Based Diagnosis and Treatment of Endometriosis via openalex
Pathogenesis of endometriosis via openalex

Cited by (11)

Source provenance

europepmc: last seen: 2026-06-11T06:19:48.454388+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-06-11T06:16:54.801207+00:00

License: CC0 · commercial use OK

[1] Advances in Treatment Options of Endometriosis via openalex

[2] A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study via openalex

[3] Analysis of the levonorgestrel-releasing intrauterine system in women with endometriosis via openalex

[4] An update on the biological markers of endometriosis via openalex

[5] A prospective cohort study of endometriosis and subsequent risk of infertility via openalex

[6] Association between chronic pelvic pain symptoms and the presence of endometriosis via openalex

[7] Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients via openalex

[8] A stepped-care approach to symptomatic endometriosis management: a participatory research initiative via openalex

[9] Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives via openalex

[10] Biomarkers in endometriosis: challenges and opportunities via openalex

[11] Biomarkers of endometriosis via openalex

[12] Blood biomarkers for the non-invasive diagnosis of endometriosis via openalex

[13] Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications via openalex

[14] Classification algorithm of patients with endometriosis: Proposal for tailored management via openalex

[15] Clinical Management of Endometriosis via openalex

[16] Clinical use of artificial intelligence in endometriosis: a scoping review via openalex

[17] Clinical use of endovenous indocyanine green during rectosigmoid segmental resection for endometriosis via openalex

[18] Coelomic Metaplasia Theory of Endometriosis: Evidence from in vivo Studies and an in vitro Experimental Model via openalex

[19] [Conservative treatment of endometriosis]. via openalex

[20] Correction to: “The Sword in the Stone”: radical excision of deep infiltrating endometriosis with bowel shaving—a single‑centre experience on 703 consecutive patients via openalex

[21] Correlation between endometriosis and pelvic pain via openalex

[22] CRITERIA THAT INDICATE ENDOMETRIOSIS IS THE CAUSE OF CHRONIC PELVIC PAIN via openalex

[23] Current and Emerging Therapeutics for the Management of Endometriosis via openalex

[24] Current Role of Modern Chromatography with Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy in the Investigation of Biomarkers of Endometriosis via openalex

[25] Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review via openalex

[26] Deep Dyspareunia and Sexual Quality of Life in Women With Endometriosis via openalex

[27] Deep pelvic endometriosis: don’t forget round ligaments. Review of anatomy, clinical characteristics, and MR imaging features via openalex

[28] Development and Validation of an Endometriosis Diagnostic Method Based on Serum Biomarkers and Clinical Variables via openalex

[29] Diagnosis and Nursing Intervention of Gynecological Ovarian Endometriosis with Magnetic Resonance Imaging under Artificial Intelligence Algorithm via openalex

[30] Diagnosis of deep endometriosis: clinical examination, ultrasonography, magnetic resonance imaging, and other techniques via openalex

[31] Diagnosis of endometriosis in the 21st century via openalex

[32] Diagnostic accuracy and potential limitations of transvaginal sonography for bladder endometriosis via openalex

[33] Effectiveness of presacral neurectomy in women with severe dysmenorrhea caused by endometriosis who were treated with laparoscopic conservative surgery: A 1-year prospective randomized double-blind controlled trial via openalex

[34] Efficacy and safety of oral gonadotropin-releasing hormone antagonists in moderate-to-severe endometriosis-associated pain: a systematic review and network meta-analysis via openalex

[35] Emerging drugs for endometriosis via openalex

[36] Endometrial biomarkers for the non-invasive diagnosis of endometriosis via openalex

[37] Endometriosis via openalex

[38] Endometriosis via openalex

[39] Endometriosis: A multimodal imaging review via openalex

[40] Endometriosis and Infertility via openalex

[41] Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women via openalex

[42] Endometriosis and infertility: Insights into the causal link and management strategies via openalex

[43] Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options via openalex

[44] Endometriosis. Current issues in diagnosis and medical management. via openalex

[45] Endometriosis: Epidemiology, Diagnosis and Clinical Management via openalex

[46] Endometriosis Pain Management: a Review via openalex

[47] Endometriosis: pathophysiology, diagnosis, and treatment. via openalex

[48] Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium via openalex

[49] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[50] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[51] Evaluation of quality of life in fertile Turkish women with severe endometriosis via openalex

[52] Evidence for the role of multidisciplinary team care in people with pelvic pain and endometriosis: A systematic review via openalex

[53] Extrapelvic Endometriosis: A Systematic Review via openalex

[54] Fertility- and Nerve-sparing Laparoscopic Eradication of Deep Endometriosis with Total Posterior Compartment Peritonectomy: The Kurashiki Method via openalex

[55] Fertility-related considerations in endometriosis via openalex

[56] Fertility sparing double discoid excision of rectosigmoid deep endometriosis under robotic-integrated ultrasound guidance via openalex

[57] Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options via openalex

[58] Going beyond the surface: a mixed-method exploration of infertility-related quality of life of women with endometriosis via openalex

[59] Guidelines for biomarker discovery in endometrium: correcting for menstrual cycle bias reveals new genes associated with uterine disorders via openalex

[60] Hormonal contraception in women with endometriosis: a systematic review via openalex

[61] Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics via openalex

[62] Imaging Modalities for Diagnosis of Deep Pelvic Endometriosis: Comparison between Trans-Vaginal Sonography, Rectal Endoscopy Sonography and Magnetic Resonance Imaging. A Head-to-Head Meta-Analysis via openalex

[63] Imaging modalities for the non-invasive diagnosis of endometriosis via openalex

[64] Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women. via openalex

[65] Introduction via openalex

[66] Laparoscopic conservative surgery for stage IV symptomatic endometriosis: short-term surgical complications via openalex

[67] Laparoscopic Management of Ureteral Endometriosis: The Stanford University Hospital Experience With 96 Consecutive Cases via openalex

[68] Laparoscopic surgery for endometriosis via openalex

[69] Laparoscopic versus laparotomic radical en bloc hysterectomy and colorectal resection for endometriosis via openalex

[70] Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis via openalex

[71] Limitations of transvaginal sonography for the diagnosis of adenomyosis, with histopathological correlation via openalex

[72] Liquid Biopsy in Endometriosis: A Systematic Review via openalex

[73] Magnetic resonance imaging for deep infiltrating endometriosis: current concepts, imaging technique and key findings via openalex

[74] Management of endometriosis from diagnosis to treatment: roadmap for the future via openalex

[75] Medical management of endometriosis via openalex

[76] Medical Management of Endometriosis via openalex

[77] Medical management of endometriosis: a systematic review. via openalex

[78] Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials via openalex

[79] Multi-disciplinary centres/networks of excellence for endometriosis management and research: a proposal via openalex

[80] Multiple nodule removal in multifocal colorectal endometriosis instead of “en bloc” large colorectal resection via openalex

[81] Near-Infrared Imaging with Indocyanine Green for Detection of Endometriosis Lesions (Gre-Endo Trial): A Pilot Study via openalex

[82] New biomarkers in endometriosis via openalex

[83] New developments in the medical treatment of endometriosis via openalex

[84] New Insights in Pathogenesis of Endometriosis via openalex

[85] New Insights into Genetics of Endometriosis—A Comprehensive Literature Review via openalex

[86] New paradigms in the diagnosis and management of endometriosis via openalex

[87] Non-invasive diagnosis of endometriosis: Immunologic and genetic markers via openalex

[88] Non-invasive methods of diagnosis of endometriosis via openalex

[89] Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis via openalex

[90] Novel agents for the medical treatment of endometriosis via openalex

[91] Novel pharmacological therapies for the treatment of endometriosis via openalex

[92] Novel targets for the treatment of endometriosis via openalex

[93] Novel Therapies Targeting Endometriosis via openalex

[94] Occult microscopic endometriosis: undetectable by laparoscopy in normal peritoneum via openalex

[95] Omics-based novel strategies in the diagnosis of endometriosis via openalex

[96] Pain and Quality of Life after Laparoscopic Excision of Endometriosis via openalex

[97] Painful Love: Superficial Dyspareunia and Three Dimensional Transperineal Ultrasound Evaluation of Pelvic Floor Muscle in Women with Endometriosis via openalex

[98] Pain in endometriosis: effectiveness of medical and surgical management via openalex

[99] Pathogenesis Based Diagnosis and Treatment of Endometriosis via openalex

[100] Pathogenesis of endometriosis via openalex