Association between CALLY index and postoperative visceral pain in endometriosis: a retrospective analysis

Belgin Savran Üçok, Türkan Dikici Aktaş, Emel Ozalp, Özgür Volkan Akbulut, Kubilay Çanga
In: Journal of Medicine and Palliative Care · 2026 · vol. 7(2) , pp. 192–197 · doi:10.47582/jompac.1841459 · W7141842605
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective study found that the CALLY index was associated with both preoperative and postoperative visceral pain in endometriosis patients, and identified it as a predictor of postoperative pain.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective comparative study evaluated women aged 18–45 who underwent surgery for stage III–IV endometriosis at Ankara Etlik City Hospital (2022–2024), alongside healthy control women undergoing bilateral tubal ligation, assessing preoperative and postoperative (day 7±1) visceral pain using VAS and calculating the C-reactive protein–albumin–lymphocyte (CALLY) index from blood samples. The authors found that both preoperative and postoperative VAS scores were significantly higher in the endometriosis group than controls, and that postoperative CALLY index values decreased relative to preoperative levels. A weak but statistically significant negative correlation was observed between postoperative CALLY index and VAS scores (ρ = –0.214, p = 0.038), and multivariate linear regression (adjusting for surgical type) identified bilateral endometrioma as the only independent predictor of postoperative visceral pain. This paper is centrally about endometriosis — it links systemic inflammatory-nutritional status (CALLY index) and postoperative visceral pain, highlighting bilateral endometrioma as a key pain predictor.

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Abstract

Aims: To investigate the relationship between preoperative and postoperative visceral pain scores and the C-reactive protein albumin–lymphocyte (CALLY) index in patients with endometriosis and to identify predictors of postoperative pain. Methods: This retrospective comparative study included women aged 18–45 years who underwent surgical treatment for stage III–IV endometriosis at Ankara Etlik City Hospital between 2022 and 2024, with postoperative histopathological confirmation of the diagnosis. The control group consisted of healthy women without pelvic pathology who underwent bilateral tubal ligation for sterilization at the same institution during the study period. Preoperative and postoperative (day 7±1) blood samples were analyzed for CRP, albumin, and lymphocytes to calculate the CALLY index. Visceral pain was evaluated using a Visual Analogue Scale (VAS). Univariate and multivariate linear regression analyses were performed to identify predictors of postoperative pain after adjusting for surgical type (laparotomy/laparoscopy). Results: Ninety-four endometriosis patients and 120 controls were analyzed. Preoperative and postoperative VAS scores were significantly higher in the endometriosis group than controls (p

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Outcome instruments

VAS-pain

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

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