Endometriosis and infertility: Insights into the causal link and management strategies

Carla Tomassetti, D'Hooghe T, Thomas D'Hooghe, Thomas D’Hooghe
Best practice & research. Clinical obstetrics & gynaecology · 2018 · vol. 51 , pp. 25–33 · doi:10.1016/j.bpobgyn.2018.06.002 · PMID:30245115 · W2808843313
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review examines the intricate relationship between endometriosis and infertility, exploring potential causal mechanisms and current therapeutic approaches for affected individuals.

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Abstract

When evaluating the correlation between endometriosis and infertility with application of the evidence-based guidelines to establish causality in medicine, it becomes apparent that endometriosis causes infertility. This is supported by a strong and consistent association between the two in various settings (prevalence, natural conception, intrauterine insemination (IUI), and assisted reproductive technologies (ARTs)), evidence for a temporal relation, arguments for a dose-response gradient, and proven effects of the removal of lesions on infertility. Next to surgical treatment of endometriosis lesions, medically assisted reproduction treatments such as IUI and ART such as in vitro fertilization are cornerstones of the management of endometriosis-related infertility. Because the revised American Society for Reproductive Medicine (rASRM) staging system is poorly correlated with pregnancy rates as opposed to the Endometriosis Fertility Index (EFI), the latter should be used as the preferred clinical tool to counsel patients on their postoperative fertility management options.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Animals Causality Endometriosis Endometriosis Female Humans Ovary Ovary Practice Guidelines as Topic Pregnancy Pregnancy Rate Reproductive Techniques, Assisted Retrospective Studies Severity of Illness Index Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (52)

Cited by (50)

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