Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome

S Nuojua-Huttunen, C Tomas, R Bloigu, L Tuomivaara, H Martikainen
Human Reproduction · 1999 · vol. 14(3) , pp. 698–703 · doi:10.1093/humrep/14.3.698 · PMID:10221698 · W1979787337
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This retrospective analysis of 811 IUI cycles found that pregnancy rates were significantly influenced by the number of treatment cycles, duration of infertility, age, number of follicles, and infertility aetiology.

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Abstract

A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed five predictive variables as regards pregnancy: number of the treatment cycle (P = 0.009), duration of infertility (P = 0.017), age (P = 0.028), number of follicles (P = 0.031) and infertility aetiology (P = 0.045). The odds ratios for age < 40 years, unexplained infertility aetiology (versus endometriosis) and duration of infertility < or = 6 years were 3.24, 2.79 and 2.33, respectively. A multifollicular ovarian response to clomiphene citrate/HMG resulted in better treatment success than a monofollicular response, and 97% of the pregnancies were obtained in the first four treatment cycles. The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women < 40 years of age with infertility duration < or = 6 years, who do not suffer from endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility Insemination, Artificial, Homologous Insemination, Artificial, Homologous Ovulation Induction Ovulation Induction Pregnancy Outcome Clomiphene Clomiphene Cost-Benefit Analysis Female Health Care Costs Humans Infertility Logistic Models Male Menotropins Menotropins Pregnancy Pregnancy, Multiple Prognosis

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