Human Reproduction

STUDY QUESTION: How do the three most widely accessible large language models perform in terms of accuracy, consistency, and reliability when answering clinically relevant questions derived from the 2022 ESHRE guideline on endometriosis? S…

STUDY QUESTION: Are there distinct symptom clusters in women with endometriosis and adenomyosis, and how do these clusters predict quality of life? SUMMARY ANSWER: Latent class analyses of 22 438 women with endometriosis identified four sy…

STUDY QUESTION: How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches? SUMMARY ANSWER: This exploration of the gut-reproductive axis in patients with endometriosis found…

STUDY QUESTION: How is endometrial and systemic immunity modulated throughout the menstrual cycle and are there changes in women with endometriosis? SUMMARY ANSWER: Endometriosis is associated with reduced endometrial early natural killer …

The endometrium is a highly dynamic and complex tissue lining the uterus, playing a central role in reproductive health. Despite its importance, the pathogenesis of many benign endometrial disorders remains poorly understood, largely due to…

STUDY QUESTION: Do women with endometriosis have a higher use of antidepressants and anxiolytics, and more frequent psychiatric hospital contacts due to depression or anxiety, before and after receiving their endometriosis diagnosis, compar…

STUDY QUESTION: How does the frequency and location of endometriosis lesions observed at laparoscopy vary with patient age? SUMMARY ANSWER: We find that older patients have more deep lesions and ovarian endometriomas at laparoscopy, althou…

STUDY QUESTION: Are there histological and immunohistochemical patterns of superficial peritoneal endometriotic lesions of symptomatic patients that characterize non-response to dienogest treatment and may suggest progesterone resistance? …

STUDY QUESTION: What is the incidence of premature ovarian insufficiency (POI) and its associated factors in Ontario, Canada, between 1995 and 2019? SUMMARY ANSWER: The incidence of POI increased after 2011, driven primarily by non-iatroge…

Abstract Study question Does serum and follicular fluid sRAGE associate with clinical heterogeneity and inflammatory markers in women with endometriosis undergoing IVF Summary answer Serum and follicular fluid sRAGE levels reflect clinical …

Chronic pelvic pain (CPP) is a prevalent, disabling syndrome encompassing overlapping disorders such as endometriosis/adenomyosis, bladder pain syndrome/interstitial cystitis, irritable bowel syndrome, vulvodynia, and myofascial pain syndro…

STUDY QUESTION: Does a natural cycle result in higher clinical pregnancy rates (CPR) with foetal heartbeat compared to an artificial cycle for frozen-thawed embryo transfer (FET) preparation in ovulatory women? SUMMARY ANSWER: The CPR with…

STUDY QUESTION: Among women pregnant after IVF/ICSI, do obstetric outcomes differ for women diagnosed with endometriosis and/or adenomyosis according to definitions by International Deep Endometriosis (IDEA) and the revised Morphological Ut…

STUDY QUESTION: Can patient-derived organoid models be reliably established from diverse surgical phenotypes of endometriosis, and how do clinical factors such as hormonal treatment affect their growth success and morphology? SUMMARY ANSWE…

STUDY QUESTION: Can a serum miRNA signature serve as a potential diagnostic biomarker for endometriosis (END)? SUMMARY ANSWER: A miRNA-based diagnostic model demonstrated an accuracy of 65.8% in distinguishing END patients from control sub…

STUDY QUESTION: Does the endometrium of oligo-ovulatory women with polyendocrine metabolic ovarian syndrome (PMOS) exhibit menstrual cycle phase-specific transcriptomic alterations compared to women without PMOS? SUMMARY ANSWER: Compared t…

STUDY QUESTION: How do unoperated ovarian endometriomas affect ovarian response during ovarian stimulation cycles? SUMMARY ANSWER: Ovaries affected by unoperated ovarian endometriomas show similar outcomes to unaffected ovaries following c…

Artificial intelligence (AI) is revolutionizing how we practice medicine. In areas where we have traditionally struggled, such as diagnosing endometriosis, AI has significant potential to improve the breadth and accuracy of diagnostic servi…

Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clini…

STUDY QUESTION: Does the restoration of regulatory T cells (Tregs) suppress the progression of endometriosis? SUMMARY ANSWER: Adoptive transfer of Tregs suppresses the progression of endometriosis and reduces the levels of helper T (Th)-ce…

STUDY QUESTION: Is childhood adversity associated with the subsequent diagnosis of endometriosis? SUMMARY ANSWER: Childhood adversities, including parental substance abuse, parental intellectual disability, parental psychiatric disorder, h…

STUDY QUESTION: Can a large-scale genome-wide association study (GWAS) meta-analysis identify genomic risk loci and likely involved genes for female genital tract (FGT) polyps, provide insights into the biological mechanism underlying their…

STUDY QUESTION: How can we best achieve tissue segmentation and cell counting of multichannel-stained endometriosis sections to understand tissue composition? SUMMARY ANSWER: A combination of a machine learning-based tissue analysis softwa…