Endométriose et infertilité

In: Physiologie, pathologie et thérapie de la reproduction chez l’humain · 2011 · pp. 315–323 · doi:10.1007/978-2-8178-0061-5_27 · W27218517
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Endometriosis is a common gynecological disease affecting women of reproductive age, with established links to infertility, although the precise causal factors remain poorly understood due to disease diversity and unclear pathophysiology.

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This chapter reviews endometriosis as a frequent gynecologic disease (estimated prevalence 6–10%) affecting women of reproductive age and discusses the link between endometriosis and infertility, while noting that the specific causative factors for infertility in endometriosis remain incompletely understood. It attributes this uncertainty in part to the heterogeneity of endometriosis and the limited elucidation of its pathophysiology. As a caveat, the chapter emphasizes that despite many studies demonstrating an association with infertility, the underlying mechanisms are still not well established. This paper is centrally about endometriosis — specifically, it examines endometriosis-related infertility and the unresolved mechanisms underlying impaired fertility.

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Résumé L’endométriose est une maladie gynécologique fréquente dont la prévalence dans la population générale est estimée entre 6 et 10% (1). Elle atteint des femmes en âge de procréer. De nombreuses études ont montré que l’endométriose était responsable d’infertilité mais les facteurs causant l’infertilité en cas d’endométriose restent mal établis. Ceci est dû pour une part à la grande diversité de l’endométriose et au fait que sa physiopathologie reste mal élucidée. Preview Unable to display preview. Download preview PDF. Références Olive DL, Schwartz LB (1993) Endometriosis. N Engl J Med 328:1759–1769 Asrm (Associated Society of Reproductive Medicine) (2004) Endometriosis and infertility. Fertil Steril 81:1441–1446 Hughes EG, Fedorkow DM, Collins JA (1993) A quantitative overview of controlled trials in endometriosis-associated infertility. Fertil Steril 59:963–970 Strathy JH, Molgaard CA, Coulam CB et al. (1982) Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 38:667–672 Gazvani R, Templeton A (2002) Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis. Reproduction 123:217–226 Hou Z, Zhou J, Ma X et al. (2008) Role of interleukin-1 receptor type II in the pathogenesis of endometriosis. Fertil Steril 89:42–51 Giudice LC (1994) Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil Steril 61:1–17 Yoshida S, Harada T, Iwabe T et al. (2004) A combination of interleukin-6 and its soluble receptor impairs sperm motility: implications in infertility associated with endometriosis. Hum Reprod 19:1821–1825 Garcia-Velasco JA, Arici A (1999) Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin. Fertil Steril 72:336–340 Calhaz-Jorge C, Costa AP, Santos MC et al. (2003) Peritoneal fluid concentrations of interleukin-8 in patients with endometriosis depend on the severity of the disorder and are higher in the luteal phase. Hum Reprod 18:593–597 Wu MY, Ho HN, Chen SU et al. (1999) Increase in the production of interleukin-6, interleukin-10, and interleukin-12 by lipopolysaccharide-stimulated peritoneal macrophages from women with endometriosis. Am J Reprod Immunol 41:106–111 Gazvani R, Smith L, Fowler PA (2002) Effect of interleukin-8 (IL-8), anti-IL-8, and IL-12 on endometrial cell survival in combined endometrial gland and stromal cell cultures derived from women with and without endometriosis. Fertil Steril 77:62–67 Li XF, Charnock-Jones DS, Zhang E et al. (2001) Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 86:1823–1834 Arici A, Matalliotakis I, Goumenou A et al. (2003) Altered expression of interleukin-18 in the peritoneal fluid of women with endometriosis. Fertil Steril 80:889–894 Arici A, Oral E, Attar E et al. (1997) Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil Steril 67:1065–1072 Xu H, Schultze-Mosgau A, Agic A et al. (2006) Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization. Fertil Steril 86:1616–1620 Garcia-Velasco JA, Mulayim N, Kayisli UA et al. (2002) Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis. Fertil Steril 78:855–859 Noble LS, Takayama K, Zeitoun KM et al. (1997) Prostaglandin E2 stimulates aromatase expression in endometri-osis-derived stromal cells. J Clin Endocrinol Metab 82:600–606 Arici A, Matalliotakis I, Goumenou A et al. (2003) Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis. Am J Reprod Immunol 49:70–74 Suzumori N, Ozaki Y, Ogasawara M et al. (2001) Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis. Mol Hum Reprod 7:459–462 Bedaiwy MA, Falcone T, Goldberg J M et al. (2006) Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients. Hum Reprod 21:788–791 Faber BM, Chegini N, Mahony M C et al. (2001) Macrophage secretory products and sperm zona pellucida binding. Obstet Gynecol 98:668–673 Said TM, Agarwal A, Falcone T et al. (2005) Infliximab may reverse the toxic effects induced by tumor necrosis factor alpha in human spermatozoa: an in vitro model. Fertil Steril 83:1665–1673 Minici F, Tiberi F, Tropea A et al. (2008) Endometriosis and human infertility: a new investigation into the role of eutopic endometrium. Hum Reprod 23:530–537 Szczepanska M, Skrzypczak J, Kamieniczna M et al. (2001) Antizona and antisperm antibodies in women with endometriosis and/or infertility. Fertil Steril 75:97–105 Garrido N, Navarro J, Remohi J et al. (2000) Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update 6:67–74 Pellicer A, Valbuena D, Bauset C et al. (1998) The follicular endocrine environment in stimulated cycles of women with endometriosis: steroid levels and embryo quality. Fertil Steril 69:1135–1141 Smith MP, Keay SD, Margo FC et al. (2002) Total cortisol levels are reduced in the periovulatory follicle of infertile women with minimal-mild endometriosis. Am J Reprod Immunol 47:52–56 Cunha-Filho JS, Lemos NA, Freitas FM et al. (2003) Insulin-like growth factor (IGF)-1 and IGF binding protein-1 and-3 in the follicular fluid of infertile patients with endometriosis. Hum Reprod 18:423–428 Cahill DJ, Wardle PG, Maile LA et al. (1997) Ovarian dysfunction in endometriosis-associated and unexplained infertility. J Assist Reprod Genet 14:554–557 Lemos NA, Arbo E, Scalco R et al. (2008) Decreased anti-Mullerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis. Fertil Steril 89:1064–1068 Bergqvist A, Bruse C, Carlberg M et al. (2001) Interleukin 1beta, interleukin-6, and tumor necrosis factor-alpha in endometriotic tissue and in endometrium. Fertil Steril 75:489–495 Genbacev OD, Prakobphol A, Foulk RA et al. (2003) Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science 299:405–408 Kao LC, Germeyer A, Tulac S et al. (2003) Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 144:2870–2871 Pellicer A, Oliveira N, Ruiz A et al. (1995) Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction. Hum Reprod 10Suppl. 2:91–97 Simon C, Gutierrez A, Vidal A et al. (1994) Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 9:725–729 Diaz I, Navarro J, Blasco L et al. (2000) Impact of stage III–IV endometriosis on recipients of sibling oocytes: matched case-control study. Fertil Steril 74:31–34 Hughes E, Brown J, Collins JJ et al. (2007) Ovulation suppression for endometriosis. Cochrane Database Syst Rev 3:CD000155 Sallam HN, Garcia-Velasco JA, Dias S et al. (2006) Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev 1:CD004635 Adamson GD, Pasta DJ (1994) Surgical treatment of endometriosis-associated infertility: meta-analysis compared with survival analysis. Am J Obstet Gynecol 171:1488–1504 Jacobson TZ, Barlow DH, Koninckx PR et al. (2002) Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev 4:CD001398 Marcoux S, Maheux R, Berube S (1997) Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med 337:217–222 Parazzini F (1999) Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi. Hum Reprod 14:1332–1334 Somigliana E, Daguati R, Vercellini P et al. (2009) The use and effectiveness of in vitro fertilization in women with endometriosis: the surgeon’s perspective. Fertil Steril 91:1775–1779 Nuojua-Huttunen S, Tomas C, Bloigu R et al. (1999) Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod 14:698–703 Barnhart K, Dunsmoor-Su R, Coutifaris C (2002) Effect of endometriosis on in vitro fertilization. Fertil Steril 77:1148–1155 Al-Azemi M, Bernal AL, Steele J et al. (2000) Ovarian response to repeated controlled stimulation in in-vitro fertilization cycles in patients with ovarian endometriosis. Hum Reprod 15:72–75 Matalliotakis IM, Cakmak H, Mahutte N et al. (2007) Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril 88:1568–1572 Somigliana E, Infantino M, Benedetti F et al. (2006) The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins. Fertil Steril 86:192–196 Busacca M, Riparini J, Somigliana E et al. (2006) Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol 195:421–425 Author information Authors and Affiliations Rights and permissions Copyright information © 2011 Springer-Verlag France, Paris About this chapter Cite this chapter Gayet, V., De Ziegler, D., Borghèse, B., Aubriot, F.X., Chapron, C. (2011). Endométriose et infertilité. In: Physiologie, pathologie et thérapie de la reproduction chez l’humain. Springer, Paris. https://doi.org/10.1007/978-2-8178-0061-5_27 Download citation DOI: https://doi.org/10.1007/978-2-8178-0061-5_27 Publisher Name: Springer, Paris Print ISBN: 978-2-8178-0060-8 Online ISBN: 978-2-8178-0061-5 eBook Packages: MedicineMedicine (R0)

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