Increase in the Production of Interleukin‐6, Interleukin‐10, and Interleukin‐12 by Lipopolysaccharide‐Stimulated Peritoneal Macrophages from Women with Endometriosis

M Y Wu, Ming‐Yih Wu, H N Ho, Hong‐Nerng Ho, Shee‐Uan Chen, S U Chen, Kuang‐Han Chao, K H Chao, C D Chen, Chin‐Der Chen, Y S Yang, Yu‐Shih Yang
American journal of reproductive immunology (New York, N.Y. : 1989) · 1999 · vol. 41(1) , pp. 106–111 · doi:10.1111/j.1600-0897.1999.tb00082.x · PMID:10097794 · W2074194256
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Lipopolysaccharide-stimulated peritoneal macrophages from women with early-stage endometriosis produced more nitric oxide, IL-6, and IL-10, while those with advanced-stage endometriosis produced more IL-12 than controls.

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Abstract

PROBLEM: To verify whether the peritoneal macrophage (PM) is activated in endometriosis. METHOD OF STUDY: We examined the synthesis of nitric oxide (NO), total antioxidant, interleukin (IL)-6, IL-10, and IL-12 by cultured PMs, which were either unstimulated or stimulated with lipopolysaccharide (LPS), from women with endometriosis (early, n = 12; advanced, n = 11) or without endometriosis (n = 13). RESULTS: After stimulation with 2 ng/mL LPS for 24 hr, PMs from women with early-stage endometriosis secreted more NO, IL-6, and IL-10 than the controls. Higher IL-12 levels were noted in women with advanced endometriosis when compared with the controls. After 2 ng/mL-LPS stimulation for 24 hr, we also detected higher total antioxidant levels in the advanced-endometriosis group than those in the early-endometriosis group. CONCLUSION: The increased production of IL-6, IL-10, and IL-12 by stimulated PMs confirmed previous observations that the PM is the principle source of these cytokines in peritoneal fluid.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukins Lipopolysaccharides Macrophage Activation Macrophages, Peritoneal Endometriosis Female Humans Interleukin-10 Interleukin-10 Interleukin-12 Interleukin-12 Interleukin-6 Interleukin-6 Interleukins Lipopolysaccharides Macrophages, Peritoneal

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (41)

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