The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube

A Papathanasiou, Athanasios Papathanasiou, Djahanbakhch O, O. Djahanbakhch, Saridogan E, Ertan Sarıdoğan, E Saridogan, R A Lyons, Lyons RA
Fertility and sterility · 2007 · vol. 90(2) , pp. 391–394 · doi:10.1016/j.fertnstert.2007.07.1379 · PMID:17888432 · W2069037891
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This study investigated the impact of interleukin-6 on the beating of cilia in the human fallopian tube.

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Abstract

OBJECTIVE: To investigate the effect of interleukin-6 (IL-6) on ciliary activity within the human fallopian tube in vitro. DESIGN: An experimental laboratory-based study. SETTING: University teaching hospital. PATIENT(S): Fallopian tube specimens were obtained from eight women undergoing hysterectomy for fibroid uterus. MAIN OUTCOME MEASURE(S): Ciliary beat frequency (CBF) in the human fallopian tube. INTERVENTION(S): After baseline CBF measurements, increasing concentrations of IL-6 (10 pg/mL, 100 pg/mL, and 1000 pg/mL) were applied to fallopian tube mucosa explants and CBF measurements repeated. An anti-IL-6 monoclonal antibody was added and CBF measured once more. Negative and antibody-only control samples were used. RESULT(S): The CBF remained unchanged with the addition of IL-6 at concentrations of 10 pg/mL and 100 pg/mL but IL-6 at 1000 pg/mL significantly decreased CBF, an effect abolished by the addition of the specific antibody. CONCLUSION(S): These data suggest that IL-6 has an inhibitory effect on ciliary activity, suggesting a possible role for this cytokine in the subfertility process. This finding may be important in conditions where there are increased IL-6 levels in the peritoneal fluid, such as endometriosis and pelvic inflammatory disease.

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MeSH descriptors

Cilia Cilia Interleukin-6 Adult Adult Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Cilia Cilia Fallopian Tubes Fallopian Tubes Fallopian Tubes Female Female Humans Humans Interleukin-6 Interleukin-6 Interleukin-6

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