Changes of cytokines levels in peritoneal fluids of patients with endometriosis and its effect on reproductive activity

Yi Liu, Y Liu, L Luo, Luo Lilan, Haibo Zhao, H Zhao
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 2000 · vol. 20(2) , pp. 163–165 · doi:10.1007/bf02887062 · PMID:12845737 · W2033996735
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis patients showed elevated peritoneal fluid TNF and IL-6 levels, reduced sperm motility, and impaired embryo development compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study measured tumor necrosis factor (TNF) and interleukin 6 (IL-6) levels in peritoneal fluid and in peritoneal macrophage culture supernatants from 14 infertile patients with endometriosis and 11 infertile women with a normal pelvis, using ELISA. TNF and IL-6 were significantly elevated in the endometriosis group, and peritoneal fluid from these patients inhibited sperm motility parameters in vitro and reduced mouse embryo development from 2-cell to 16-cell stage after 48 hours of co-culture. The key limitation is the small sample size and the use of in vitro sperm and mouse embryo assays rather than direct confirmation of reproductive effects in humans. This paper is centrally about endometriosis — it links elevated peritoneal TNF/IL-6 to impaired fertility-related outcomes in experimental co-culture systems.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Interleukin-6 Tumor Necrosis Factor-alpha Adult Animals Ascitic Fluid Culture Media, Conditioned Cytokines Embryo, Mammalian Embryo, Mammalian Endometriosis Female Fertility Humans Interleukin-6 Macrophages, Peritoneal Macrophages, Peritoneal Mice

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References (17)

Cited by (9)

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