Cytokines in the peritoneal fluid of patients with endometriosis

N Koyama, K Matsuura, Hitoshi Okamura, H Okamura
International Journal of Gynecology & Obstetrics · 1993 · vol. 43(1) , pp. 45–50 · doi:10.1016/0020-7292(93)90273-y · PMID:7904954 · W2091352452
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found elevated levels of IL-5 and IL-6 in the peritoneal fluid of endometriosis patients, with a negative correlation between IL-5 and IL-6.

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Abstract

OBJECTIVE: To determine which of the various cytokines interleukin-5 (IL-5), interleukin-6 (IL-6) and interleukin-1 (IL-1) are important in endometriosis. METHODS: Peritoneal fluid (PF) samples were taken from 55 women at the time of either laparotomy or laparoscopy, and were examined for the levels of IL-5, IL-6 and IL-1 using each cytokine specific sandwich enzyme-linked immunosorbent assay. Thirty-two patients had pelvic endometriosis, eight post-pelvic inflammatory disease, four advanced cancer, three adenomyosis, three benign ovarian tumor, and other diseases. Statistical analysis was performed with the Mann Whitney test, chi-square test or Fisher's test. RESULTS: Both IL-5 and IL-6 levels in PF specimens with endometriosis tended to be higher than normal, while the same specimens were mostly interleukin-1 beta (IL-1 beta) negative. Of great interest was the negative correlation between log (IL-5) and IL-6 (Fisher's test, P < 0.04). CONCLUSION: These findings support the concept that IL-5 and IL-6 but not IL-1 are associated with endometriosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Adult Ascitic Fluid Ascitic Fluid Cytokines Cytokines Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Infertility, Female Infertility, Female Interleukin-5 Interleukin-5 Interleukin-6 Interleukin-6 Middle Aged Pelvic Inflammatory Disease

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (50)

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