Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma

Slater M, Michael Slater, Michael D. Slater, M. Cooper, Cooper M, Mark S. Cooper, Christopher R. Murphy, C R Murphy
Acta histochemica · 2006 · vol. 108(1) , pp. 13–18 · doi:10.1016/j.acthis.2006.01.004 · PMID:16564564 · W1981317587
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Endometriosis and endometrioid adenocarcinoma both show increased levels of human growth hormone and interleukin-6.

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Abstract

In this retrospective and quantitated study on banked tissue we found that, compared to normal uterine epithelial cells, growth hormone (GH) is increased 3.4-fold in endometriosis and 3.8-fold in endometrial adenocarcinoma. Similarly, interleukin-6 (IL-6) is increased 2.4-fold in endometriosis and 4.4-fold in endometrial adenocarcinoma. These proteins appear to be involved in the progression of both these conditions. GH is particularly interesting in this context since it is known to not only promote cellular proliferation but also reduces cell-cell adhesion, thus allowing individual cells to break away from their parent architecture. Our results suggest that both IL-6 and GH may play a role in the progression of both endometriosis and endometrial carcinoma.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Endometrial Neoplasms Endometriosis Human Growth Hormone Interleukin-6 Carcinoma, Endometrioid Carcinoma, Endometrioid Endometrial Neoplasms Endometrial Neoplasms Endometriosis Female Human Growth Hormone Humans Immunohistochemistry Interleukin-6 Peritoneal Diseases Peritoneal Diseases Up-Regulation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (9)

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