Endometriosis, Leiomyoma and Adenomyosis: the Risk of Gynecologic Malignancy
This review evaluates the relationship between endometriosis, leiomyoma, and adenomyosis and gynecologic cancers, finding they may be associated with an increased risk of endometrial and ovarian cancers.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
This paper reviews the evidence linking endometriosis, uterine leiomyomas, and adenomyosis to subsequent gynecologic malignancies, integrating epidemiologic studies and mechanistic findings from molecular and pathological literature. Across the cited body of work, it highlights associations between these benign or hormonally responsive gynecologic conditions and cancers arising within or in association with them (including endometriosis-associated ovarian cancer and reported malignant transformations involving adenomyosis), while discussing molecular pathways implicated in tumor risk. A major limitation is that the provided text functions as a reference list rather than presenting new original data, so conclusions depend on heterogeneity across study designs, populations, and endpoints. This paper’s relationship to endometriosis and adenomyosis is direct by title and by citing endometriosis- and adenomyosis-associated malignancy evidence throughout the included references.
Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works
Abstract
Full text
21,952 characters
· extracted from
oa-html
· click to expand
Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.
My notes (saved in your browser only)
Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (93)
- Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion via openalex
- Adenomyosis is Associated With Myometrial Invasion by FIGO 1 Endometrial Adenocarcinoma via openalex
- Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of a common lineage. via openalex
- A selective estrogen receptor-β agonist causes lesion regression in an experimentally induced model of endometriosis via openalex
- Cancer risk after a hospital discharge diagnosis of endometriosis via openalex
- Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis via openalex
- Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis via openalex
- Causes of Infertility as Predictors of Subsequent Cancer Risk via openalex
- Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium? via openalex
- Endocrine and inflammatory factors and endometriosis-associated infertility in assisted reproduction techniques via openalex
- Endometrial Adenocarcinoma Involving Adenomyosis without True Myometrial Invasion Is Characterized by Frequent Preceding Estrogen Therapy, Low Histologic Grades, and Excellent Prognosis via openalex
- Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex
- Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma via openalex
- Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells via openalex
- Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis via openalex
- Interleukin‐1 Stimulates Macrophage Migration Inhibitory Factor Secretion in Ectopic Endometrial Cells of Women with Endometriosis via openalex
- Involvement of pelvic inflammation–related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis via openalex
- Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis via openalex
- K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma via openalex
- Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex
- Malignant changes in adenomyosis in patients with endometrioid adenocarcinoma. via openalex
- Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). via openalex
- New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal via openalex
- Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex
- Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management via openalex
- Ovarian cancer risk associated with varying causes of infertility via openalex
- Ovarian clear cell carcinoma—bad endometriosis or bad endometrium? via openalex
- Pathogenesis and the Role of ARID1A Mutation in Endometriosis-related Ovarian Neoplasms via openalex
- Pathogenesis of Endometriosis via openalex
- Patterns of Loss of Heterozygosity at 10q23.3 and Microsatellite Instability in Endometriosis, Atypical Endometriosis, and Ovarian Carcinoma Arising in Association With Endometriosis via openalex
- Pitfall in the diagnosis of endometrial cancer: case report of an endometrioid adenocarcinoma arising from uterine adenomyosis. via openalex
- Postmenopausal cancer risk after self‐reported endometriosis diagnosis in the Iowa Women's Health Study via openalex
- Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer via openalex
- Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex
- Relationship of Benign Gynecologic Diseases to Subsequent Risk of Ovarian and Uterine Tumors via openalex
- Risk of carcinoma in women with ovarian endometrioma via openalex
- Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan via openalex
- Risk of Endometrial Cancer in Relation to Medical Conditions and Medication Use via openalex
- Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery via openalex
- Serous Endometrial Intraepithelial Carcinoma Arising in Adenomyosis via openalex
- The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer via openalex
- The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis via openalex
- The Origin of Ovarian Cancer — Is It Getting Clearer? via openalex
- The relationship of endometriosis and ovarian malignancy: a review via openalex
- The role of prostaglandin E <sub>2</sub> in endometriosis via openalex
- Unraveling the two entities of endometrioid ovarian cancer: A single center clinical experience via openalex
- Up-Regulation of Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Endometriotic Cells by Macrophage Migration Inhibitory Factor: Involvement of Novel Kinase Signaling Pathways via openalex
- W2008389846 via openalex
- W2058174458 via openalex
- W2058742695 via openalex
- W2000311445 via openalex
- W2065635506 via openalex
- W2066781414 via openalex
- W1991808539 via openalex
- W2070289148 via openalex
- W1983710061 via openalex
- W2090702820 via openalex
- W2094818680 via openalex
- W2096422981 via openalex
- W1981926952 via openalex
- W2100351768 via openalex
- W2106220473 via openalex
- W2109525253 via openalex
- W2110702895 via openalex
- W133186721 via openalex
- W1979440636 via openalex
- W2127174260 via openalex
- W1978802594 via openalex
- W2128875155 via openalex
- W2129876810 via openalex
- W2140028786 via openalex
- W1975902298 via openalex
- W2146239695 via openalex
- W2148521420 via openalex
- W2155564780 via openalex
- W2158187504 via openalex
- W1973664534 via openalex
- W1972781416 via openalex
- W2161817637 via openalex
- W1966151739 via openalex
- W2167649358 via openalex
- W2322847397 via openalex
- W1577593758 via openalex
- W2032450536 via openalex
- W1489538543 via openalex
- W2030866834 via openalex
- W2010917135 via openalex
- W2037812289 via openalex
- W2043395636 via openalex
- W2046141468 via openalex
- W2047959475 via openalex
- W2010223577 via openalex
- W2009607870 via openalex
Cited by (37)
- Dynamics of psycho-emotional changes after functionally sparing gynaecological operations 2026
- Retrospective Study on the Incidence of Benign, Premalignant, and Malignant Gynecologic Disorders in Patients with Adenomyosis: Analysis of 5648 Specimens 2024
- Study on differentially expressed genes and participating pathways of ectopic endometrium in adenomyosis patients with different data sets 2023
- Characteristics and Prognosis of Ovarian Pure Clear Cell Carcinoma: A Retrospective Experience of 136 Patients 2023
- Reproductive outcome and gynecologic comorbidities in women with endometriosis in a non-IVF setting: a retrospective study 2023
- The correlation between women's various gynaecological diseases to ovarian cancer in Sulaimaniyah City, Iraq 2023
- The effect of ENEAS application in patients with endometriosis and its influence on the level of IL-8 and MCP-1 2022
- Adenomyosis as a Risk Factor for Myometrial or Endometrial Neoplasms—Review 2022
- There is no significant correlation of adenomyosis with benign, premalignant and malignant gynecological pathologies. Retrospective study on 647 specimens 2022
- Study of prevalence of endometrial cancer in patients with adenomyosis uteri 2021
- The role of immune-related redox biology in malignant transformation of endometriosis 2021
- A case of adenomyosis with leiomyoma that was effectively treated with relugolix and kamishoyosan add-on therapy 2021
- Mice Uterine Stem Cells are Affected by Neonatal Endocrine Disruption & Initiate Uteropathies in Adult Life Independent of Circulatory Ovarian Hormones 2021
- Histopathological Association of Adenomyosis with Various Gynaecological Pathologies 2020
- Adenomyosis: clinical aspects, impact on fertility and pregnancy outcome 2020
- Abnormal gut microbiota-induced hypoestrogenemia as a possible risk factor for malignancy in endometrioid heterotopia 2020
- Retrospective evaluation of pathological results among women with ovarian endometriomas versus teratomas 2019
- Mechanisms Underlying Adenomyosis-Related Fibrogenesis 2019
- Current facts constituting an understandingof the nature of adenomyosis 2018
- LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM IN ADENOMYOSIS; PREDICTORS FOR RESPONSE AND CLINICAL OUTCOME 2018
- THE CLINICAL EFFICACY OF SEQUENTIAL USE OF GONADOTROPIN-RELEASING HORMONE ANALOG - LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM IN MEDICALLY ILL WOMEN WITH SYMPTOMATIC AND RELATIVELY LARGE ADENOMYOSIS 2018
- Adenomyosis and Endometrial Cancer: Literature Review 2018
- PREVALENCIA DE COMORBILIDADES EN PACIENTES CON ENDOMETRIOSIS EN EDAD FÉRTIL EN EL HOSPITAL MARÍA AUXILIADORA ENTRE LOS AÑOS 2008-2017 2018
- DEGENERAÇÃO MALIGNA DA ENDOMETRIOSE: REVISÃO DA LITERATURA 2017
- Co‑existence of benign gynecological tumors with endometriosis in a group of 1,000 women 2017
- Adenomyosis: Back to the future? 2017
- Clear cell adenocarcinoma arising from abdominal wall endometriosis 2016
- Comparative evaluation of morphological criteria of endometrial dysfunction in patients with infertility associated with pelvic inflammatory disease, external genital endometriosis and uterine myoma 2016
- [Clear cell adenocarcinoma arising from abdominal wall endometriosis] 2016
- COMPLEX ASSESSMENT OF REPRODUCTIVE HEALTH IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS AFTER SURGERY 2016
- Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union 2016
- Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease 2015
- MiR-202 promotes endometriosis by regulating SOX6 expression. 2015
- The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis. 2015
- Follicle-Stimulating Hormone Receptor Expression in Endometriotic Lesions and the Associated Vasculature: An Immunohistochemical Study 2015
- Rare case of endometrioid adenocarcinoma arising from cystic adenomyosis 2014
- Use of enhanced T2 star-weighted angiography (ESWAN) and R2* values to distinguish ovarian cysts due to endometriosis from other causes 2014
Source provenance
- europepmc
- last seen: 2026-06-23T06:15:44.889181+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:18:47.062786+00:00