Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management

Masaki Mandai; Ken Yamaguchi; Noriomi Matsumura; Tsukasa Baba; Ikuo Konishi

doi:10.1007/s10147-009-0935-y

Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management

Masaki Mandai, Ken Yamaguchi, Noriomi Matsumura, Tsukasa Baba, Ikuo Konishi

International journal of clinical oncology · 2009 · vol. 14(5) , pp. 383–391 · doi:10.1007/s10147-009-0935-y · PMID:19856044 · W1994553563

review OA: closed CC0 ⤵ 84 in-corpus citations

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Ovarian Neoplasms

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (79)

Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma via openalex
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis via openalex
A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. via openalex
Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of a common lineage. via openalex
Ovarian atypical endometriosis: its close association with malignant epithelial tumours via openalex
Coincidence of Granulosa‐Cell Tumour of Ovary and Development of Carcinoma in Rectal Endometriosis via openalex
Common Genetic Changes between Endometriosis and Ovarian Cancer via openalex
Comparative immunohistochemical studies of bcl‐2 and p53 proteins in benign and malignant ovarian endometriotic cysts via openalex
Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress via openalex
Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridization (FISH) via openalex
Does endometriosis really have premalignant potential? A clonal analysis of laser‐microdissected tissue via openalex
ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN via openalex
Endometrioid Adenocarcinoma of the Ovary and Its Relationship to Endometriosis via openalex
Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex
Endometriosis as a model for inflammation–hormone interactions in ovarian and breast cancers via openalex
Endometriosis-Associated Ovarian Carcinoma (EAOC): An Entity Distinct from Other Ovarian Carcinomas as Suggested by a Nested Case-Control Study via openalex
Epithelial Abnormalities in Cystic Ovarian Endometriosis via openalex
Epithelial metaplastic changes in ovarian endometriosis. via openalex
Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. via openalex
Higher frequency of chromosomal aberrations in ovarian endometriosis compared to extragonadal endometriosis: a possible link to endometrioid adenocarcinoma via openalex
Histologic Transformation of Benign Endometriosis to Early Epithelial Ovarian Cancer via openalex
Hormone replacement therapy in women with past history of endometriosis via openalex
Hyperestrogenism: A Relevant Risk Factor for the Development of Cancer from Endometriosis via openalex
Increased prevalence of p53 overexpression from typical endometriosis to atypical endometriosis and ovarian cancer associated with endometriosis via openalex
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma via openalex
Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex
Malignancy arising in endometriosis associated with unopposed estrogen replacement. via openalex
Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types via openalex
Malignant changes in endometriosis. via openalex
Malignant transformation of endometriosis and genetic alterations of K‐ras and microsatellite instability via openalex
Malignant transformation of residual endometriosis in women on unopposed oestrogen hormone replacement therapy via openalex
Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian tumor suppressor gene loci. via openalex
Molecular genetic evidence that endometriosis is a precursor of ovarian cancer via openalex
Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex
Ovarian Adenosarcoma With Extensive Deciduoid Morphology Arising in Endometriosis: A Case Report via openalex
Ovarian and extraovarian endometriosis-associated cancer via openalex
Ovarian Endometrioid Adenocarcinoma Arising from an Endometriotic Cyst in a Postmenopausal Woman under Tamoxifen Therapy for Breast Cancer: A Case Report via openalex
Ovarian endometrioma—Risks factors of ovarian cancer development via openalex
Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study via openalex
Ovarian mixed-epithelial papillary cystadenomas of borderline malignancy of mullerian type: A clinicopathologic analysis via openalex
Ovarian Mucinous and Mixed Epithelial Carcinomas of Mullerian (Endocervical-like) Type: A Clinicopathologic Analysis of Four Cases of an Uncommon Variant Associated with Endometriosis via openalex
Ovarian tumors associated with atypical endometriosis via openalex
p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer via openalex
Pathology of endometriosis. via openalex
Patterns of Loss of Heterozygosity at 10q23.3 and Microsatellite Instability in Endometriosis, Atypical Endometriosis, and Ovarian Carcinoma Arising in Association With Endometriosis via openalex
Possible involvement of hMLH1, p16INK4a and PTEN in the malignant transformation of endometriosis via openalex
Prognosis of Japanese Patients with Ovarian Clear Cell Carcinoma Associated with Pelvic Endometriosis: Clinicopathologic Evaluation via openalex
Prognostic Importance of Hyperplasia and Atypia in Endometriosis via openalex
Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay via openalex
Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan via openalex
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer via openalex
Sex Cord Tumor with Annular Tubules Associated with Endometriosis of the Fallopian Tube via openalex
Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis via openalex
Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor via openalex
The pathology of endometriosis via openalex
The relationship of endometriosis and ovarian malignancy: a review via openalex
Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor via openalex
Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis via openalex
W1791183955 via openalex
W1546101705 via openalex
W2163064788 via openalex
W174381814 via openalex
W2053309322 via openalex
W4238413599 via openalex
W2041439843 via openalex
W2066508854 via openalex
W2034846334 via openalex
W2019601632 via openalex
W2087081961 via openalex
W2017911026 via openalex
W2016353415 via openalex
W2102562347 via openalex
W2103522194 via openalex
W2007157284 via openalex
W1982465546 via openalex
W1982331680 via openalex
W2131277105 via openalex
W2137602402 via openalex
W1974601263 via openalex

Cited by (50)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
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License: CC0 · commercial use OK

[1] Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma via openalex

[2] Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis via openalex

[3] A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. via openalex

[4] Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of a common lineage. via openalex

[5] <b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b> via openalex

[6] Coincidence of Granulosa‐Cell Tumour of Ovary and Development of Carcinoma in Rectal Endometriosis via openalex

[7] Common Genetic Changes between Endometriosis and Ovarian Cancer via openalex

[8] Comparative immunohistochemical studies of <i>bcl</i>‐2 and p53 proteins in benign and malignant ovarian endometriotic cysts via openalex

[9] Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress via openalex

[10] Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridization (FISH) via openalex

[11] Does endometriosis really have premalignant potential? A clonal analysis of laser‐microdissected tissue via openalex

[12] ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN via openalex

[13] Endometrioid Adenocarcinoma of the Ovary and Its Relationship to Endometriosis via openalex

[14] Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex

[15] Endometriosis as a model for inflammation–hormone interactions in ovarian and breast cancers via openalex

[16] Endometriosis-Associated Ovarian Carcinoma (EAOC): An Entity Distinct from Other Ovarian Carcinomas as Suggested by a Nested Case-Control Study via openalex

[17] Epithelial Abnormalities in Cystic Ovarian Endometriosis via openalex

[18] Epithelial metaplastic changes in ovarian endometriosis. via openalex

[19] Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. via openalex

[20] Higher frequency of chromosomal aberrations in ovarian endometriosis compared to extragonadal endometriosis: a possible link to endometrioid adenocarcinoma via openalex

[21] Histologic Transformation of Benign Endometriosis to Early Epithelial Ovarian Cancer via openalex

[22] Hormone replacement therapy in women with past history of endometriosis via openalex

[23] Hyperestrogenism: A Relevant Risk Factor for the Development of Cancer from Endometriosis via openalex

[24] Increased prevalence of p53 overexpression from typical endometriosis to atypical endometriosis and ovarian cancer associated with endometriosis via openalex

[25] K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma via openalex

[26] Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex

[27] Malignancy arising in endometriosis associated with unopposed estrogen replacement. via openalex

[28] Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types via openalex

[29] Malignant changes in endometriosis. via openalex

[30] Malignant transformation of endometriosis and genetic alterations of K‐ras and microsatellite instability via openalex

[31] Malignant transformation of residual endometriosis in women on unopposed oestrogen hormone replacement therapy via openalex

[32] Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian tumor suppressor gene loci. via openalex

[33] Molecular genetic evidence that endometriosis is a precursor of ovarian cancer via openalex

[34] Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex

[35] Ovarian Adenosarcoma With Extensive Deciduoid Morphology Arising in Endometriosis: A Case Report via openalex

[36] Ovarian and extraovarian endometriosis-associated cancer via openalex

[37] Ovarian Endometrioid Adenocarcinoma Arising from an Endometriotic Cyst in a Postmenopausal Woman under Tamoxifen Therapy for Breast Cancer: A Case Report via openalex

[38] Ovarian endometrioma—Risks factors of ovarian cancer development via openalex

[39] Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study via openalex

[40] Ovarian mixed-epithelial papillary cystadenomas of borderline malignancy of mullerian type: A clinicopathologic analysis via openalex

[41] Ovarian Mucinous and Mixed Epithelial Carcinomas of Mullerian (Endocervical-like) Type: A Clinicopathologic Analysis of Four Cases of an Uncommon Variant Associated with Endometriosis via openalex

[42] Ovarian tumors associated with atypical endometriosis via openalex

[43] p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer via openalex

[44] Pathology of endometriosis. via openalex

[45] Patterns of Loss of Heterozygosity at 10q23.3 and Microsatellite Instability in Endometriosis, Atypical Endometriosis, and Ovarian Carcinoma Arising in Association With Endometriosis via openalex

[46] Possible involvement of <i>hMLH1, p16</i><sup><i>INK4a</i></sup> and <i>PTEN</i> in the malignant transformation of endometriosis via openalex

[47] Prognosis of Japanese Patients with Ovarian Clear Cell Carcinoma Associated with Pelvic Endometriosis: Clinicopathologic Evaluation via openalex

[48] Prognostic Importance of Hyperplasia and Atypia in Endometriosis via openalex

[49] Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay via openalex

[50] Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan via openalex

[51] Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer via openalex

[52] Sex Cord Tumor with Annular Tubules Associated with Endometriosis of the Fallopian Tube via openalex

[53] Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis via openalex

[54] Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor via openalex

[55] The pathology of endometriosis via openalex

[56] The relationship of endometriosis and ovarian malignancy: a review via openalex

[57] Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor via openalex

[58] Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis via openalex

[59] W1791183955 via openalex

[60] W1546101705 via openalex

[61] W2163064788 via openalex

[62] W174381814 via openalex

[63] W2053309322 via openalex

[64] W4238413599 via openalex

[65] W2041439843 via openalex

[66] W2066508854 via openalex

[67] W2034846334 via openalex

[68] W2019601632 via openalex

[69] W2087081961 via openalex

[70] W2017911026 via openalex

[71] W2016353415 via openalex

[72] W2102562347 via openalex

[73] W2103522194 via openalex

[74] W2007157284 via openalex

[75] W1982465546 via openalex

[76] W1982331680 via openalex

[77] W2131277105 via openalex

[78] W2137602402 via openalex

[79] W1974601263 via openalex