Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridization (FISH)

Jong-Chul Shin, J C Shin, Helen L. Ross, H L Ross, Sherman Elias, S Elias, D D Nguyen, Dianne Nguyen, Dorothy Mitchell‐Leef, D Mitchell-Leef, J L Simpson, Joe Leigh Simpson, F Z Bischoff, Farideh Z. Bischoff
Human genetics · 1997 · vol. 100(3-4) , pp. 401–406 · doi:10.1007/s004390050524 · PMID:9272163 · W1982948669
article OA: closed CC0 ⤵ 44 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This study used multi-color FISH to assess chromosomal numeric alterations in endometriosis, finding increased monosomy for chromosomes 17 and 16, and trisomy for chromosome 11 in some samples.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper investigated whether severe/late-stage endometriosis tissue contains somatic chromosomal numeric alterations by using multi-color fluorescence in situ hybridization (FISH) with alpha-satellite probes for chromosomes 7, 8, 11, 12, 16, 17, and 18. The authors compared frequencies of mono-, di-, and trisomic cells between normal controls and endometriotic specimens using simultaneous two- and three-color FISH, finding significant, chromosome-specific aneuploidy events in different samples: increased monosomy for chromosomes 17 and 16 in one case, chromosome 11 trisomy in a second case, and chromosome 16 monosomy in a third case. A stated caveat is that the findings were based on only four endometriosis samples, with alterations observed in just some cases. This paper is centrally about endometriosis — it uses multi-color FISH to detect chromosome-specific aneuploidy patterns in severe/late-stage endometriosis tissues.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aneuploidy Endometriosis In Situ Hybridization, Fluorescence Color Endometriosis Female Humans In Situ Hybridization, Fluorescence

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