Chromosome variant 1qh− and its influence on the 3D organization of chromosome 1 heterochromatin in interphase nucleus of patients with endometriosis

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This study investigated how the chromosome variant 1qh− affects the three-dimensional organization of chromosome 1 heterochromatin in the interphase nuclei of endometriosis patients.

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This study investigated how the chromosome variant 1qh− affects the 3D organization of chromosome 1 heterochromatin in the interphase nuclei of patients with endometriosis, using 3D nuclear organization methods to compare heterochromatin positioning patterns. The key finding reported is that the presence of the 1qh− variant influences chromosome 1 heterochromatin spatial arrangement. A major caveat is that the work is limited to the specific chromosome variant and to patients included in the study, without broader functional linkage to disease mechanisms described in the available text. This paper is centrally about endometriosis — it focuses on 1qh−-associated changes in chromosome 1 heterochromatin 3D organization in patients with endometriosis.

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References

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Acknowledgements

This work was partly supported by target financing SF0180096s08 from the Estonian Ministry of Education and Research. We are thankful to Prof. A. žarkovski from the Institute of Pharmacology, University of Tartu, for fruitful suggestions; assistants Marika Masso and Anu Kaldmaa from the Institute of Biomedicine, University of Tartu, for help in the collection of materials for the study. Author information Authors and Affiliations Corresponding author Additional information [Mikelsaar R., Paves H., Org K. and Mikelsaar A.-V. 2014 Chromosome variant 1qh- and its influence on the 3D-organization of chromosome 1 heterochromatin in interphase nucleus of patients with endometriosis. J. Genet. 93, xx–xx] Rights and permissions About this article Cite this article MIKELSAAR, R., PAVES, H., ORG, K. et al. Chromosome variant 1qh− and its influence on the 3D organization of chromosome 1 heterochromatin in interphase nucleus of patients with endometriosis. J Genet 93, 219–223 (2014). https://doi.org/10.1007/s12041-014-0340-9 Received: Revised: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s12041-014-0340-9

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Condition tags

endometriosis

MeSH descriptors

Cell Nucleus Chromosomes, Human, Pair 1 Endometriosis Heterochromatin Interphase Adult Chromosome Banding Endometriosis Female Humans In Situ Hybridization, Fluorescence Microscopy, Confocal Middle Aged Young Adult

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