Allelic loss studies do not provide evidence for the “endometriosis-as-tumor” theory

Amanda Prowse, Prowse AH, Amanda H Prowse, Giannoulis Fakis, Fakis G, Manek S, Sanjiv Manek, Michael Churchman, Sarah E. Edwards, Edwards S, Sarah Edwards, Andrew Rowan, Rowan A, Philippe R. Koninckx, Koninckx P, Philippe Koninckx, Stephen Kennedy, Kennedy S, Ian P M Tomlinson, Tomlinson IP, Ian Tomlinson
Fertility and sterility · 2005 · vol. 83(4) , pp. 1134–1143 · doi:10.1016/j.fertnstert.2004.07.982 · PMID:15831286 · W2090811757
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This study investigated allelic loss patterns in endometriosis tissues to determine if they exhibit tumor-like genetic alterations.

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Abstract

ObjectiveTo identify consistent genetic changes in endometriosis samples to determine whether endometriosis lesions are true neoplasms.DesignWe analyzed ovarian endometriosis lesions for loss of heterozygosity (LOH) at 12 loci of potential importance (D9S1870, D9S265, D9S270, D9S161, D11S29, D1S199, D8S261, APOA2, PTCH, TP53, D10S541, and D10S1765), including some at which genetic changes were previously reported in endometriosis.SettingMolecular biology laboratory in a university hospital department.Patient(s)Seventeen women with ovarian endometriosis.Intervention(s)Laser capture microdissection to separate the endometriotic epithelium, the adjacent endometriotic stroma, and surrounding normal ovarian stromal tissue, followed by DNA extraction and polymerase chain reaction amplification of polymorphic microsatellite markers.Main outcome measure(s)Fluorescence-based quantitation for the LOH analysis.Result(s)We identified LOH in only one lesion at one locus (D8S261).Conclusion(s)Our data do not support the hypothesis that ovarian endometriosis is a true neoplasm.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Loss of Heterozygosity Ovarian Neoplasms Ovarian Neoplasms Adult Alleles Endometriosis Epithelial Cells Epithelial Cells Female Humans Microsatellite Repeats Middle Aged Ovarian Neoplasms Stromal Cells Stromal Cells

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