Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization
Comparative genomic hybridization of 18 endometriotic tissues revealed recurrent DNA copy number losses on multiple chromosomes, particularly 1p and 22q, in 15 cases.
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This study investigated genomic copy number alterations associated with endometriosis by performing comparative genomic hybridization on DNA from 18 manually dissected endometriotic tissue samples, aiming to identify chromosomal gains and losses involved in lesion development. The authors found recurrent copy number losses in 15 of 18 cases, with chromosome 1p and 22q losses each occurring in 50% of cases, plus additional common losses on 5p, 6q, 7p, 9q, 16, and a gain observed on 6q, 7q, and 17q in a subset. CGH findings were validated using dual-color FISH for regions on chromosomes 1, 7, and 22, showing that CGH-detected deletions corresponded to reduced signal proportions relative to centromeric labels. A limitation explicitly reflected in the validation results is that deletions were present in less than 30% of nuclei for cases with CGH loss, indicating mosaicism or partial involvement. This paper is centrally about endometriosis—identifying recurrent DNA copy number losses and gains in endometriotic lesions via CGH and FISH validation.
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Cited by (22)
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- A New Hypothesis for Endometriosis: To Change the Classification and Consider A New Concept of its Origin 2019
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- Aberrant histone modification in endometriosis 2014
- Endometrial Stem Cells and Endometriosis 2012
- Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma 2011
- Deregulation of LOXL1 and HTRA1 Gene Expression in Endometriosis 2010
- Endometriosis 2010
- Análise da Expressão Gênica Diferencial em Endometriose 2008
- Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential 2008
- Hibridação Genômica Comparativa em Endometriose 2008
- Glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis 2008
- Expressão gênica diferencial em tecido endometrial tópico e lesões endometrióticas 2007
- Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis 2006
- Endometriosis-Specific Genes Identified by Real-Time Reverse Transcription-Polymerase Chain Reaction Expression Profiling of Endometriosis Versus Autologous Uterine Endometrium 2006
- Allelic loss studies do not provide evidence for the “endometriosis-as-tumor” theory 2005
- ENDOMETRIOSIS FAMILIAR: REPORTE DE UNA FAMILIA CON HERENCIA MENDELIANA 2005
- The best-fit model for endometriosis 2003
- Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay 2003
- Emerging role of genomics in endometriosis research 2002
- 10.1016/s0246-1064(17)65070-9 2000
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