Endometrial Stem Cells and Endometriosis

Jafar Ai, Esmaeil Sadroddiny
In: Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/32015 · W1566247445
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Endometrial stem cells possess high proliferative, differentiation, and angiogenic capabilities, showing potential for tissue engineering and cell therapy applications.

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This chapter reviews the emerging role of endometrial stem cells in the pathogenesis of endometriosis, focusing on their potential to contribute to lesion formation and recurrence. The authors discuss how these multipotent cells may be shed during menstruation and implant at ectopic sites, thereby driving the disease process through differentiation into various tissue types found in endometriotic implants. A significant caveat noted is that while animal models support this hypothesis, direct evidence from human studies remains limited and requires further validation. This paper is centrally about endometriosis — specifically examining the mechanistic role of endometrial stem cells in its development.

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Abstract

On this basis, endometrial stem cells (EnSCs), characterized by higher abilities for proliferation, differentiation, fast angiogenesis during menstruation and immune tolerance for embryo during pregnancy, have been considered as a valuable source of stem cells (Gargett, Chan et al. 2007; Meng, Ichim et al. 2007). Several researches have demonstrated presence of highly pleuripotent mesenchymal stem cells in endometrium by differentiation potency to various cell types such as, insulin producer cells (Li, Chen et al. 2010), osteoblasts (Ai, Mehrabani. 2010) , odontoblasts (Ai, Tabatabaei et al. 2009), neurons (Wolff, Gao et al. 2011) (Ai, Tabatabaei et al. 2009) and Myoblast (Ai, Tabatabaei et al. 2009). These findings may open up new opportunities to use endometrial stem cells in tissue engineering and cell therapy (Ai , Mehrabani. 2009).
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Open access Submitted: 06 April 2011 Published: 09 May 2012 DOI: 10.5772/32015 From the Edited Volume Edited by Koel Chaudhury and Baidyanath Chakravarty Submitted: 06 April 2011 Published: 09 May 2012 © 2012 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Discover 2026 Nobel Laureate Francis Halzen’s chapter on IntechOpen >

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endometriosis

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