Glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis

Meola J, Juliana Meola, Daniel Blasioli Dentillo, Daniel Blassioli Dentillo, Rosa E Silva JC, Júlio César Rosa e Silva, Rui Alberto Ferriani, Ferriani RA, Veiga LC, Luciana Caricati da Silva Veiga, Luciana Caricati Veiga, Paro de Paz CC, Cláudia Cristina Paro de Paz, Silvana Giuliatti, Martelli L, Lúcia Regina Martelli, Lúcia Martelli
Fertility and sterility · 2008 · vol. 91(5) , pp. 1676–1680 · doi:10.1016/j.fertnstert.2008.02.158 · PMID:18402941 · W2016623680
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This study investigated glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis.

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Abstract

ObjectiveTo analyze the expression of the glycodelin gene to better understand the molecular environment of endometriotic lesions and to elucidate the potential mechanisms that underlie the complex physiopathology of endometriosis.DesignProspective laboratory study.SettingUniversity hospital.Patient(s)Eleven healthy fertile women and 17 patients with endometriosis in the early proliferative phase of the menstrual cycle.Intervention(s)Endometrial biopsy specimens were obtained from the endometrium of healthy women without endometriosis (controls) and from eutopic and ectopic endometrium tissues (pelvic and ovarian endometriotic implants) of endometriosis patients.Main outcome measure(s)The glycodelin relative expression level by real-time polymerase chain reaction (PCR) analysis.Result(s)The glycodelin down-regulation found in the endometriotic lesions was 332.26 and 123.17-fold lower, respectively, when compared with the eutopic tissue and the control endometrium.Conclusion(s)Glycodelin may be one of the molecules that contributes to the loss of cellular homeostasis in endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Choristoma Endometriosis Endometrium Glycoproteins Pregnancy Proteins Adolescent Adult Choristoma Endometriosis Endometrium Female Glycodelin Glycoproteins Humans Pregnancy Proteins Prospective Studies

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