Endometriozisli hastaların ektopik ve ötopik dokularında glycodelin A mRNA ekspresyonlarının belirlenmesi

Khayala Rasulova, Melek Pehli̇van, Aygün AKBEROVA, Sefa Kızıldağ
In: Cukurova Medical Journal · 2021 · vol. 46(1) , pp. 310–317 · doi:10.17826/cumj.795826 · W3124115735
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This study found that Glycodelin A mRNA expression was higher in ectopic and eutopic endometrial tissues of endometriosis patients compared to controls, particularly in the secretory phase.

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The study measured glycodelin A mRNA expression in ectopic and eutopic (orthotopic) endometrial tissues from women with endometriosis, comparing secretion and proliferation stages with endometrium from healthy controls. Nineteen histopathologically confirmed endometriosis patients and seven controls (ages 26–45) provided tissue samples obtained during laparoscopy/laparotomy, after which RNA was isolated, converted to cDNA, and glycodelin A mRNA levels were quantified by real-time PCR. Glycodelin A expression was higher in ectopic and eutopic tissues from endometriosis patients in both the secretory and proliferative phases versus controls, and ectopic secretory-phase patients showed increased levels compared with their eutopic counterparts, while some patients had decreased expression in the proliferative phase when ectopic tissue was compared with eutopic tissue. This paper is centrally about endometriosis — it specifically evaluates glycodelin A mRNA expression differences between ectopic and eutopic endometrial tissues across secretion and proliferation phases.

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Abstract

Amaç: Çalışmamızda endometriozisli kadınların sağlıklı bireylere göre sekresyon ve proliferasyon evrelerinde, ektopik ve ötopik endometrium dokularının Glikodelin A mRNA ekspresyon seviyeleri incelenmiştir. Gereç ve Yöntem: Laparaskopi ve laparatomi sırasında tanı alan ve histopatolojik olarak tanısı doğrulanan endometriozisli 19 hasta ve 7 kontrol grubu çalışmaya dahil edildi (26-45 yaş). Endometriozisli kadınların sekresyon ve proliferasyon evrelerinde alınan ektopik ve ötopik endometrium dokuları ile kontrol grubu endometrium dokularından RNA izolasyonları gerçekleştirildikten sonra cDNA’ya çevrildi. Glikodelin A ekspresyon düzeyleri gerçek zamanlı polimeraz zincir reaksiyonu kullanılarak değerlendirildi. Bulgular: Sekretuar ve proliferasyon fazda olan endometriozisli hastaların kontrole göre olan ötopik ve ektopik dokularında Glikodelin A ekspresyon düzeylerinin daha yüksek olduğu gözlendi. Ektopik sekretuar fazda olan hastaların Glikodelin A seviyesi, ötopik hastadakilere göre artış gösterdi. Hastalarda proliferasyon fazlarındaki Glikodelin A seviyesi ötopik hastalar ile kıyaslandığında bazı hastalarda ekspresyonun düştüğü saptandı. Tartışma: Endometriozis’te Glikodelin A geninin sekretuar ve proliferatif fazda ekspresyonsinin yüksek olması ve ektopik sekretuar fazda olan hastaların Glikodelin A seviyesinin, ötopik hastadakilere göre artış göstermesi, Glikodelin A geninin değerlendirilmesinin hastalığın tanısının konulması aşamasında yönlendirici olabileceğini göstermektedir.
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Materials and methods

19 Patients with endometriosis, which were diagnosed during laparoscopy and laparotomy and confirmed histopathologically, and 7 control groups were included in the study of people between the age of 26-45. It was converted to cDNA after RNA isolation was performed from ectopic and etopic endometrial tissues taken during the secretion and proliferation stages of women with endometriosis and control group endometrial tissues. Glycodelin A expression levels were evaluated using real-time polymerase chain reaction.

Results

Glycodelin A expression levels were higher in the euphoric and ectopic tissues of the patients with endometriosis in the secretory and proliferating phases. The Glycodelin A level of patients in the ectopic secretory phase increased compared to those in the etopic patient., The expression decreased in some patients when the Glycodelin A level in the proliferation phases of the patients was compared with that of the etopic patient.

Conclusion

High expression of the Glycodelin A gene in the secretory and proliferative phases in endometriosis, and the increase in the Glycodelin A level in patients in the ectopic secretory phase, compared to the etopic patients, indicate that the evaluation of the Glycodelin A gene may be a guide in the diagnosis of the disease. Anahtar Kelimeler endometriosis, glycodelin A, mRNA

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