Theories on Endometriosis

In: SpringerBriefs in Reproductive Biology · 2015 · pp. 17–21 · doi:10.1007/978-3-319-18308-4_3 · W2269195068
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This paper reviews theories on endometriosis development, primarily focusing on Sampson's widely accepted hypothesis involving retrograde menstruation, viable cell presence, and implantation.

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This paper/chapter reviews multiple theories proposed to explain endometriosis development, emphasizing that Sampson’s theory is the most widely accepted. In Sampson’s framework first hypothesized in 1927, endometriosis requires three elements: retrograde menstruation, viable cells present within the retrograde menstruation, and implantation of these viable endometrial cells that continue to grow and form peritoneal lesions. The chapter presents the theory as a leading explanation but does not provide experimental results or a quantified comparison across competing theories, since it is a narrative review of ideas. This paper is centrally about endometriosis — it summarizes the major theories of endometriosis development, with special focus on Sampson’s retrograde menstruation/viable-cell implantation model.

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Abstract

There are several theories as to how endometriosis develops, but the most widely accepted one is Sampson’s theory. First hypothesized in 1927, Sampson’s theory [1] states that three elements are required to cause endometriosis: retrograde menstruation, the presence of viable cells within the retrograde menstruation, and the implantation of these viable endometrial cells, which continue to grow and form peritoneal lesions [1]. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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