The Role of Placental Protein 14 in the Pathogenesis of Endometriosis

Ping Wang, Libo Zhu, Xinmei Zhang
Reproductive sciences (Thousand Oaks, Calif.) · 2013 · vol. 20(12) , pp. 1465–1470 · doi:10.1177/1933719113488452 · PMID:23670949 · PMC3817670 · W1980597657
article OA: bronze CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Serum PP-14 concentrations were increased in women with endometriosis and correlated with lesion expression, but peritoneal fluid concentrations showed no significant difference.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study measured placental protein 14 (PP-14) concentrations in peritoneal fluid and serum and assessed PP-14 protein expression in endometriotic lesions in women with ovarian endometriosis (n=75) versus women without endometriosis (n=49), sampling between days 7 and 20 of the menstrual cycle using ELISA and immunohistochemistry. Serum PP-14 was significantly higher in women with endometriosis and decreased after surgery and further with gonadotropin-releasing hormone agonist therapy, while peritoneal fluid PP-14 showed no significant group difference. Within the endometriosis group, lesion PP-14 expression scores correlated with serum PP-14 levels. A key caveat is that the PP-14 difference was limited to serum, with no significant peritoneal fluid separation. This paper is centrally about endometriosis — it tests whether PP-14 levels and lesion expression are associated with its pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glycoproteins Adult Ascitic Fluid Ascitic Fluid Biomarkers Biomarkers CA-125 Antigen CA-125 Antigen Case-Control Studies Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Glycodelin Glycoproteins Humans Immunohistochemistry Menstrual Cycle

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