Diagnostic potential of peritoneal fluid biomarkers of endometriosis

Rižner TL, Tea Lanišnik Rižner
Expert review of molecular diagnostics · 2015 · vol. 15(4) , pp. 557–580 · doi:10.1586/14737159.2015.1015994 · PMID:25719220 · W2003865668
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This review analyzes peritoneal fluid molecular biomarkers identified in the past five years for their potential diagnostic, prognostic, and therapeutic applications in endometriosis.

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Abstract

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, in different parts of the peritoneal cavity. It affects up to 10% of reproductive-age women and up to 50% of women with infertility. Surgical diagnosis of endometriosis is still the gold standard, with no diagnostic biomarkers available. Medical therapies target the symptoms and not the disease itself, and surgical treatment cannot prevent recurrence. As peritoneal fluid reflects the altered peritoneal microenvironment of endometriosis patients, it can provide a wealth of information on pathophysiological processes and potential biomarkers. This report reviews the molecular biomarkers identified in peritoneal fluid over the last 5 years and discusses their potential applications for diagnosis, prognosis and drug therapy.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Adult Ascitic Fluid Biomarkers Endometriosis Endometriosis Female Humans Inflammation Inflammation Inflammation Oxidative Stress

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (95)

Cited by (36)

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License: CC0 · commercial use OK