Oxidative stress biomarkers in patients with endometriosis: systematic review

Luiz Fernando Pina Carvalho, Abhishek Neil Samadder, Ashok Agarwal, Luiz Flávio C Fernandes, Luiz Flávio Cordeiro Fernandes, Mauricio S Abrão, Maurício Simões Abrão
Archives of gynecology and obstetrics · 2012 · vol. 286(4) , pp. 1033–1040 · doi:10.1007/s00404-012-2439-7 · PMID:22791380 · W2063806095
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This review of 19 articles measured 36 oxidative stress biomarkers in endometriosis patients, finding 23 significantly elevated compared to controls.

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This paper conducted a systematic review of English-language studies published in MEDLINE from 1990 to March 2011 to identify and summarize oxidative stress biomarkers measured in patients with endometriosis, grouping them by biomarker type based on reported assays. Across 19 included articles, the authors found 36 oxidative stress biomarkers representing 20 different markers, with 23 markers reported as significantly higher in endometriosis patients than in control groups, organized into subgroups including enzymatic activity, free radicals/anions, lipoperoxidation, DNA damage, and protein oxidation. A major limitation is that the review only included manuscripts in English and excluded review articles, and it did not provide a standardized quantitative synthesis across heterogeneous biomarkers. This paper is centrally about endometriosis — it systematically reviews oxidative stress biomarkers measured in people with endometriosis.

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Abstract

Purpose Since the first description about oxygen toxicity made by Joseph Priestley, the oxidative stress has been enrolled as a key factor in the pathogenesis of endometriosis. Our aim was to review oxidative stress biomarkers measured in patients with endometriosis.

Methods

Relevant studies were identified by searches of the MEDLINE database from 1990 to March 2011 using endometriosis, free radical and oxidative stress as mesh terms. We only included manuscripts in English, and review articles were excluded. In addition, free radical chemistry and oxidative stress history were discussed.

Results

After inclusion and exclusion criteria, 19 articles were selected to be included in this systematic review. A total of 36 oxidative stress biomarkers (20 different markers) were measured in patients with endometriosis. Some of the markers were measured in more than one manuscript. They were arranged in five subgroups: Enzymatic activity (n = 3), Anions/free radicals (n = 5), Lipoperoxidation markers (n = 7), DNA Damage markers (n = 1), and Protein oxidation (n = 4). Of those 36 markers, 23 were found to be significantly higher in patients with endometriosis comparing with control patients.

Conclusion

Oxidative stress plays an important role in the pathogenesis and progression of endometriosis. Similar content being viewed by others

References

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BJOG Int J Obstet Gynaecol 118(1):6–16. doi:10.1111/j.1471-0528.2010.02777.x;10.1111/j.1471-0528.2010.02777.x Slater M, Quagliotto G, Cooper M, Murphy CR (2005) Endometriotic cells exhibit metaplastic change and oxidative DNA damage as well as decreased function, compared to normal endometrium. J Mol Histol 36(4):257–263. doi:10.1007/s10735-005-3802-9 Matsuzaki S, Schubert B (2010) Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis. Fertil Steril 93(7):2431–2432. doi:10.1016/j.fertnstert.2009.08.068 Lambrinoudaki IV, Augoulea A, Christodoulakos GE, Economou EV, Kaparos G, Kontoravdis A, Creatsas G (2009) Measurable serum markers of oxidative stress response in women with endometriosis. Fertil Steril 91(1):46–50. doi:10.1016/j.fertnstert.2007.11.021 Acknowledgments Luiz Carvalho was supported by a Brazilian government research grant from “Coordination for the improvement of higher-level personnel” (CAPES). Conflict of interest None. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Carvalho, L.F.P., Samadder, A.N., Agarwal, A. et al. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet 286, 1033–1040 (2012). https://doi.org/10.1007/s00404-012-2439-7 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-012-2439-7

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Biomarkers Endometriosis Oxidative Stress Biomarkers Endometriosis Female Humans

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