Evaluation of Oxidative Stress with "Dynamic Thiol/Disulfide Homeostasis" in Cases with Endometrioma

Şule Atalay Mert, Berna Dilbaz, Tuğba Kınay, Serdar Dilbaz, Fulya Kayıkçıoğlu, Salim Neşeli̇oğlu, Özcan Erel, Yaprak Engin Üstün
In: Medical Science and Discovery · 2022 · vol. 9(8) , pp. 458–464 · doi:10.36472/msd.v9i8.784 · W4293211500
article OA: diamond CC0
🔓 Open OA copy View on OpenAlex View at publisher

Abstract

Objective: This preliminary study aims to use "dynamic thiol/disulfide homeostasis" with the new Erel method to evaluate the effect of oxidative stress in patients with endometrioma. Material and Method: The study group consisted of 40 cases with histologically confirmed endometrioma, and 40 women with no laparoscopically confirmed endometriosis were taken as the control group. Plasma thiol, total thiol (TT), and disulfide (SS) levels were measured with the new, fully automatic method described by Erel and Neselioglu. Serum Ca-125, sedimentation (Sed), C-reactive Protein (CRP), and thiol/disulfide levels were measured. The two groups' plasma thiol, total thiol, and disulfide levels were compared, and the relation between thiol/disulfide homeostasis and stage of the endometriosis, Ca-125, Sed, and CRP was evaluated. Results: In cases with endometrioma, disulfide/native thiol (3,12±2,02, 2,05±1,21, p=0,005) and disulfide/total thiol ratios (3,50±2,52, 2,22±1,36, p=0,006) were significantly increased, native thiol (469,30±126,52, 571,72±125,32 p=0,00) total thiol levels (505,17 ± 133,88, 603,0±134,22 p=0,02) were significantly decreased when compared with the control group. There was a positive correlation between native thiol level and revised American Society for Reproductive Medicine Classification (r-ASRM) (p=0,041). Conclusion: As expected, "dynamic thiol/disulfide homeostasis" with the new Erel method, the significant decrease in total thiol and native thiol levels, which are used as oxidative stress markers, and the increase in disulfide values demonstrated by this study support the hypothesis that oxidative stress plays a role in endometriosis and these markers can be used in the management of endometriosis

My notes (saved in your browser only)

Condition tags

endometriosisendometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK