Increased concentration of 8-hydroxy-2′-deoxyguanosine in follicular fluid of infertile women with endometriosis

Michele G Da Broi, Michele Gomes Da Broi, Felipe O de Albuquerque, Felipe Oliveira de Albuquerque, Aline Z de Andrade, Rafaela L Cardoso, Alceu A Jordão Junior, Alceu Afonso Jordão, Paula A Navarro, Paula Andrea Navarro
Cell and tissue research · 2016 · vol. 366(1) , pp. 231–242 · doi:10.1007/s00441-016-2428-4 · PMID:27250533 · W2412106011
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study found higher follicular fluid concentrations of 8-hydroxy-2′-deoxyguanosine and vitamin E in infertile women with endometriosis compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study compared eight oxidative stress markers measured in serum and follicular fluid of infertile women with endometriosis versus infertile controls undergoing controlled ovarian stimulation for intracytoplasmic sperm injection, analyzing samples collected at oocyte retrieval from 29 endometriosis cases and 32 controls (plus 43 and 44 serum samples). The endometriosis group had higher serum glutathione and superoxide dismutase, lower serum total antioxidant capacity, and—within the follicular microenvironment—higher 8-hydroxy-2′-deoxyguanosine (8OHdG) and vitamin E, indicating both systemic and follicular oxidative stress with oxidative DNA damage. A key limitation acknowledged by the authors is that causality cannot be established from these observational biomarker comparisons. This paper is centrally about endometriosis — it reports increased 8OHdG in follicular fluid as evidence of oxidative DNA damage associated with endometriosis-related infertility.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Deoxyguanosine Endometriosis Follicular Fluid Infertility, Female 8-Hydroxy-2'-Deoxyguanosine Adult Biomarkers Biomarkers Case-Control Studies Deoxyguanosine Deoxyguanosine Endometriosis Endometriosis Endometriosis Female Follicular Fluid Humans Infertility, Female Infertility, Female Infertility, Female

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