Altered transcriptome in cumulus cells of infertile women with advanced endometriosis with and without endometrioma

da Luz CM, Caroline M. Da Luz, Michele G da Broi, Da Broi MG, Michele Gomes Da Broi, Plaça JR, Jéssica Rodrigues Plaça, Jessica R Plaça, Silva WA Jr, Wilson A. Silva, Juliana Meola, Meola J, Paula Andrea Navarro, Paula A Navarro, Navarro PA
Reproductive BioMedicine Online · 2021 · vol. 42(5) , pp. 952–962 · doi:10.1016/j.rbmo.2021.01.024 · PMID:33736992 · W3128264498
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This study investigated gene expression in cumulus cells from infertile women with advanced endometriosis, finding altered transcriptomes in those with and without endometriomas.

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Abstract

Research questionIs the transcriptome of cumulus cells of infertile women with advanced endometriosis (EIII/IV), with and without endometrioma, altered?DesignIn this prospective case-control study, next-generation RNA sequencing was used to compare the transcript profile of cumulus cells among infertile patients undergoing ovarian stimulation for intracytoplasmic sperm injection with EIII/IV, with (n = 9) and without endometrioma (n = 9), and controls (n = 9). An in-silico enrichment analysis was conducted to establish the possibly altered pathways in cumulus cells of patients with endometriosis.ResultsMost of the differentially expressed genes (DEG) were found when cumulus cells from women with EIII/IV with endometrioma were compared with controls (DEG, n = 461). In women with EIII/IV without endometrioma, only 66 DEG were verified compared with controls. The enrichment analysis showed that some DEG in cumulus cells of endometriosis are involved in important pathways for the oocyte competence acquisition, such as oxidative phosphorylation, metabolism, mitochondrial function, acetylation and steroid biosynthesis. No DEG were found when cumulus cells from women with EIII/IV with and without endometrioma were compared.ConclusionRNA sequencing results suggest that cumulus cells of infertile women with EIII/IV have an altered transcriptome, regardless of endometrioma. The present findings offer a better understanding of the genes and molecular mechanisms that may be involved in endometriosis-related infertility, mostly in the oocyte competence acquisition process.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cumulus Cells Endometriosis Infertility, Female Transcriptome Adult Case-Control Studies Cumulus Cells Endometriosis Endometriosis Female Gene Expression Profiling Humans Infertility, Female Infertility, Female Prospective Studies Young Adult

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