Endometriosis and Oocyte Quality

Hidekazu Saito, Tomofumi Seino, Tomoko Kaneko, Tomoko Kaneko-Tarui, Kenji Nakahara, Mayumi Toya, Hirohisa Kurachi
Gynecologic and obstetric investigation · 2002 · vol. 53(Suppl. 1) , pp. 46–51 · doi:10.1159/000049424 · PMID:11834868 · W1976299761
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Endometriosis patients exhibit increased granulosa cell apoptosis, cell cycle alterations, and oxidative stress, potentially impacting oocyte quality and fertility.

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Abstract

Endometriosis is associated with marked subfertility and various causes for this subfertility have been previously studied. The poor quality of oocytes has been suggested as one possible cause. In this study, we evaluated the quality of oocytes by examining the status of granulosa cells surrounding the oocyte. For this purpose, we analysed the incidence of apoptosis, changes in cell cycle, and oxidative stress in the granulosa cells. Endometriosis patients had a higher apoptotic incidence, more alterations of the cell cycle, and a higher incidence of oxidative stress than patients with any of the other infertility causes (tube, male, and idiopathic factors). These changes might affect oocyte quality, and thus fertility in endometriosis patients.

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Condition tags

endometriosisinfertility

MeSH descriptors

Apoptosis Endometriosis Infertility, Female Oocytes Oxidative Stress Apoptosis Cell Cycle Cell Cycle Cells, Cultured Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Oocytes Sensitivity and Specificity Severity of Illness Index

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References (24)

Cited by (49)

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