Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction

Dmowski WP, W P Dmowski, W. Paul Dmowski, Radwanska E, E Radwanska, Ewa Radwańska, Zvi Binor, Z Binor, Binor Z, Nasiruddin Rana, Rana N, N Rana
Fertility and Sterility · 1986 · vol. 46(5) , pp. 784–789 · doi:10.1016/s0015-0282(16)49811-0 · PMID:3096780 · W2410982287
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This study investigated the impact of danazol treatment on ovulation induction success in women with mild endometriosis and ovulatory dysfunction.

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Abstract

The effectiveness of ovulation induction with clomiphene citrate or human menopausal gonadotropins was evaluated in 52 infertile women with stage I or stage II endometriosis and ovulatory dysfunction: anovulation or luteinized unruptured follicle (LUF) syndrome before (group I) and after (group II) danazol treatment. The incidence of anovulation and LUF in the endometriosis population was 9% and 34%, respectively. In group I, 10 of 36 patients (27.8%) conceived, with an average of 17.6 induction cycles per pregnancy. In group II, 21 of 30 patients (70%) conceived, with an average of 4.5 cycles per pregnancy (difference significant at P less than 0.001). There was no difference in the average number of ovulation induction cycles per patient between groups I and II (4.9 and 3.1, respectively). Of 14 patients who did not conceive in group I and crossed over to group II, 9 (64.3%) conceived (not different from group II). Spontaneous abortion rates were 20% in group I and 14% in group II. These results indicate that mild endometriosis may interfere with conception through mechanisms other than ovulatory dysfunction and that treatment with danazol appears to more than double the fertility rate.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Ovarian Diseases Ovulation Induction Pregnadienes Adult Anovulation Anovulation Clomiphene Clomiphene Danazol Endometriosis Endometriosis Female Humans Menotropins Menotropins Ovarian Diseases Pregnadienes

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