Management of Pelvic Endometriosis with Low-Dose Danazol
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This paper reports on the management of pelvic endometriosis using low-dose danazol.
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Abstract
Thirty-eight women with pelvic endometriosis diagnosed by laparotomy or laparoscopy were enrolled in a double-blind study utilizing danazol. Danazol was administered for 6 months in four doses schedules: 600, 400, 200, and 100 mg/day. At the completion of 6 months of therapy, repeat laparoscopy was performed and 71% of the women were found to have improvement of pelvic endometriosis. Minimal and moderate pelvic endometriosis appeared to respond well to doses of danazol of less than 400 mg/day, whereas severe endometriosis appeared to be best treated with danazol doses of greater than 400 mg/day. Symptomatic relief of pain, dysmenorrhea, and dyspareunia occurred in 89% of the women. The over-all pregnancy rate in women attempting conception was 28% (8 of 28). Fifty-four per cent of the women had recurrence of symptoms within 1 year of discontinuation of danazol.
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Cited by (30)
- Ovulation suppression for endometriosis for women with subfertility 2007
- Ovulation suppression for endometriosis 2003
- UPDATE ON THE MEDICAL TREATMENT OF ENDOMETRIOSIS 2000
- Managing endometriosis 1999
- The evidence for the management of endometriosis 1998
- The effect of regular exercise on women receiving danazol for treatment of endometriosis 1995
- Recurrent Endometriosis 1995
- Pain recurrence: A quality of life issue in endometriosis 1995
- Goserelin (Zoladex) versus danazol for endometriosis: the North American experience 1994
- Can hormone replacement therapy be used during medical therapy of endometriosis? 1994
- 9 Endometriosis: Medical therapy 1993
- Medical management of endometriosis 1993
- The endometrium and endometriosis 1991
- The use of danazol as a treatment of endometriosis 1991
- Heterotopic pregnancy 1991
- Hormonal Therapy of Endometriosis 1989
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis 1987
- Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery 1987
- Endometriosis 1987
- Comparison of different treatment modalities of endometriosis in infertile women 1987
- Comparison of different treatment modalities of endometriosis in infertile women. 1987
- Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction 1986
- Treatment of infertility due to endometriosis with low-dosage danazol 1984
- Endometriosis 1984
- A comparative study of various dosages of danazol in the treatment of endometriosis 1984
- Regression of endometriosis following shorter treatment with, or lower dose of danazol: Comparison of pre‐ and post‐treatment laparoscopic findings in the Scandinavian multi‐center study 1984
- Endometriosis and infertility 1984
- Medical treatment of endometriosis in infertile patients 1983
- The effectiveness of danazol on subsequent fertility in minimal endometriosis 1982
- Hormonal and Surgical Management of Pelvic Endometriosis 1982
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