The effect of regular exercise on women receiving danazol for treatment of endometriosis

S E Carpenter, Sue Carpenter, Bruce L. Tjaden, B Tjaden, J A Rock, John A. Rock, A Kimball, A. W. Kimball
International Journal of Gynecology & Obstetrics · 1995 · vol. 49(3) , pp. 299–304 · doi:10.1016/0020-7292(95)02359-k · PMID:9764869 · W2033344894
article OA: closed CC0 ⤵ 22 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Regular exercise alongside danazol therapy for endometriosis reduced androgenic side effects and lowered testosterone levels but did not alter symptom relief or recurrence time.

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Abstract

OBJECTIVE: To determine the effects of regular exercise on women receiving danazol for the treatment of endometriosis. METHODS: Thirty-nine patients were randomized to a danazol-only or a danazol/exercise regimen in a prospective clinical trial carried out at tertiary care institutions. Patients in the danazol/exercise group were instructed to exercise four times per week, for 40 min per session, at an intensity of 20 metabolic units. Side effect profiles, pelvic symptoms, aerobic fitness, strength and hormone levels were compared for all subjects. The number of side effects of danazol was analyzed by the method of generalized estimating equations. RESULTS: The number of side effects reported during a 4-week period was 1.09-2.17 times greater for the danazol-only than for the danazol/exercise group. All patients had improvement of symptoms during treatment. The danazol/exercise group had significantly lower testosterone levels during treatment. The time to recurrence of endometriosis was not different between groups. CONCLUSIONS: Exercise during danazol therapy reduces the number of androgenic side effects. Relief of pain and time to recurrence are unaffected.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Estrogen Antagonists Exercise Therapy Adult Combined Modality Therapy Danazol Endometriosis Endometriosis Estrogen Antagonists Female Humans Pain Pain Pain Recurrence Testosterone Testosterone Time Factors Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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