Management of pelvic endometriosis with low-dose danazol

Moore EE, Edward E. Moore, E E Moore, James H. Harger, J H Harger, Harger JH, Rock JA, J A Rock, John A. Rock, Archer DF, David F. Archer, D F Archer
Fertility and Sterility · 1985 · vol. 44(2) , pp. 50–54 · doi:10.1016/s0015-0282(16)48802-3 · PMID:6454591 · W2412391366
article OA: closed CC0 ⤵ 23 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper examines the efficacy of low-dose danazol for managing pelvic endometriosis, reporting on its effects and clinical outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Thirty-eight women with pelvic endometriosis diagnosed by laparotomy or laparoscopy were enrolled in a double-blind study utilizing danazol. Danazol was administered for 6 months in four doses schedules: 600, 400, 200, and 100 mg/day. At the completion of 6 months of therapy, repeat laparoscopy was performed and 71% of the women were found to have improvement of pelvic endometriosis. Minimal and moderate pelvic endometriosis appeared to respond well to doses of danazol of less than 400 mg/day, whereas severe endometriosis appeared to be best treated with danazol doses of greater than 400 mg/day. Symptomatic relief of pain, dysmenorrhea, and dyspareunia occurred in 89% of the women. The over-all pregnancy rate in women attempting conception was 28% (8 of 28). Fifty-four per cent of the women had recurrence of symptoms within 1 year of discontinuation of danazol.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Pelvic Neoplasms Pregnadienes Adult Clinical Trials as Topic Danazol Dose-Response Relationship, Drug Double-Blind Method Endometriosis Endometriosis Female Humans Laparoscopy Laparotomy Pelvic Neoplasms Pelvic Neoplasms Pregnadienes Pregnancy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (23)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:06.101301+00:00
License: CC0 · commercial use OK