9 Endometriosis: Medical therapy

Mary Wingfield; M Wingfield; David Healy; D L Healy

doi:10.1016/s0950-3552(05)80465-1

9 Endometriosis: Medical therapy

Mary Wingfield, M Wingfield, David Healy, D L Healy

Bailliere's clinical obstetrics and gynaecology · 1993 · vol. 7(4) , pp. 813–838 · doi:10.1016/s0950-3552(05)80465-1 · PMID:8131317 · W1991434189

review OA: closed CC0 ⤵ 33 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper reviews current medical therapies for endometriosis, focusing on hormonal treatments and pain management strategies.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Endometriosis Estrogens Estrogens Estrogens Female Gestrinone Gestrinone Gestrinone Goserelin Goserelin Goserelin Humans Infertility, Female

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References (100)

Abbreviated endometriosis-associated infertility correlates with in vitro fertilization success via openalex
A Comparative Treatment Trial of Endometriosis Using the Gonadotrophin‐releasing Hormone Agonist, Nafarelin, and the Synthetic Steroid, Danazol via openalex
Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex
A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex
A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis via openalex
Bone mass in endometriosis patients treated with GnRH agonist implant or danazol. via openalex
Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: A randomized clinical trial via openalex
Buserelin versus danazol in the treatment of endometriosis-associated infertility via openalex
Cholesterol fractions and apolipoproteins during endometriosis treatment by a gonadotrophin releasing hormone (GnRH) agonist implant or by danazol via openalex
Comparison of different treatment modalities of endometriosis in infertile women via openalex
Comparison of different treatment modalities of endometriosis in infertile women. via openalex
Contraception: a risk factor for endometriosis. via openalex
Cumulative pregnancy rates in infertile women with endometriosis. via openalex
Cyclic use of Combination Oral Contraceptives and the Severity of Endometriosis via openalex
Danazol and medroxyprogesterone acetate inefficacious in the treatment of infertility in endometriosis via openalex
Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties via openalex
Danazol inhibits steroidogenesis by the human ovary in vivo via openalex
Dosage aspects of danazol therapy in endometriosis: Short-term and long-term effectiveness via openalex
DYDROGESTERONE AND ENDOMETRIOSIS via openalex
Effects of Progestin-Induced Pseudopregnancy on Endometriosis: Clinical and Microscopic Studies via openalex
Efficacy of danazol treatment for minimal endometriosis in infertile women. A prospective, randomized study. via openalex
Efficacy of intranasal or subcutaneous luteinizing hormone-releasing hormone agonist inhibition of ovarian function in the treatment of endometriosis via openalex
Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis via openalex
Endometriosis. via openalex
Endometriosis 1991: a discussion document via openalex
Endometriosis and infertility via openalex
Endometriosis—Associated Infertility via openalex
Endometriosis-associated infertility: evaluation of preoperative use of danazol, gestrinone, and buserelin. via openalex
Endometriosis: Associations with Menorrhagia, Infertility and Oral Contraceptives via openalex
Endometriosis therapy with medroxyprogesterone acetate. via openalex
Epidemiology of endometriosis in women attending family planning clinics. via openalex
Evaluation of oral medroxyprogesterone acetate in the treatment of endometriosis. via openalex
Evidence of similar increases in bone turnover during nafarelin and danazol use in women with endometriosis via openalex
Gamete intrafallopian transfer as treatment for infertility associated with endometriosis via openalex
Gestogens and anti-gestogens as treatment of endometriosis via openalex
Gonadotrophin releasing hormone agonist (buserelin) in the treatment of endometriosis: changes in the extent of the disease and in CA 125 serum levels after 6‐month therapy via openalex
Gonadotropin releasing hormone agonist therapy and its effect on bone mass via openalex
Hormonal and biochemical changes during treatment of endometriosis with the luteinizing hormone-releasing hormone (LH-RH) agonist <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mrow><mml:mo stretchy="false">[</mml:mo><mml:mtext>D</mml:mtext><mml:mo>-</mml:mo><mml:msup><mml:mrow><mml:mtext>Trp</mml:mtext></mml:mrow><mml:mn>6</mml:mn></mml:msup><mml:mo>,</mml:mo><mml:mtext>des</mml:mtext><mml:mo>-</mml:mo><mml:mtext>Gly</mml:mtext><mml:mo>-</mml:mo><mml:msubsup><mml:mrow><mml:mtext>NH</mml:mtext></mml:mrow><mml:mn>2</mml:mn><mml:mrow><mml:mn>10</mml:mn></mml:mrow></mml:msubsup><mml:mo stretchy="false">]</mml:mo></mml:mrow></mml:math>LH-RH ethylamide via openalex
Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex
Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis a rodent model via openalex
Immunosuppressive effects of danazol in vitro via openalex
Impact of gestrinone on the course of asymptomatic endometriosis. via openalex
Is It Possible to Prevent Bone Loss in Young Women Treated with Luteinizing Hormone-Releasing Hormone Agonists? via openalex
Lupron depot (leuprolide acetate for depot suspension) in the treatment of endometriosis: a randomized, placebo-controlled, double-blind study via openalex
MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex
Management of pelvic endometriosis with low-dose danazol via openalex
Management of Pelvic Endometriosis with Low-Dose Danazol via openalex
Medical Management of Endometriosis via openalex
Medical treatment of endometriosis: a comparative trial. via openalex
Medical treatment of endometriosis: a comparison of the suppressive effects of danazol and nafarelin on reproductive hormones via openalex
Menotropin stimulation after prolonged gonadotropin releasing hormone agonist pretreatment for in vitro fertilization in patients with endometriosis via openalex
Metabolic changes during medical treatment of endometriosis: Nafarelin acetate versus danazol via openalex
Modern Approaches to Endometriosis via openalex
Nafarelin for endometriosis: a large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex
Nafarelin for endometriosis: A large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex
OPINION: Endometriosis: a new approach is needed via openalex
Periovulatory calcium channel blockade enhances reproductive performance in an animal model for endometriosis-associated subfertility. via openalex
Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery via openalex
Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate via openalex
Significant postmenopausal endometriosis. via openalex
SIGNIFICANT POSTMENOPAUSAL ENDOMETRIOSIS via openalex
Successful treatment of asymptomatic endometriosis: does it benefit infertile women? via openalex
The effectiveness of danazol on subsequent fertility in minimal endometriosis via openalex
The effect of endometriomas on in vitro fertilization outcome via openalex
The effects of combining norethindrone with a gonadotropin-releasing hormone agonist in the treatment of symptomatic endometriosis via openalex
The effects of combining norethindrone with a gonadotropin‐releasing hormone agonist in the treatment of symptomatic endometriosis via openalex
The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer via openalex
The morphologic effect of short-term medical therapy of endometriosis via openalex
The Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise via openalex
The role of definitive surgery and hormone replacement therapy in the treatment of endometriosis via openalex
The second-look laparoscopy for evaluation of the result of medical treatment of endometriosis should not be performed during ovarian suppression via openalex
The treatment of infertility associated with endometriosis by in vitro fertilization via openalex
The use of danazol as a treatment of endometriosis via openalex
THE USE OF STILBESTROL FOR ENDOMETRIOSIS via openalex
The value of pre-treatment with gonadotrophin releasing hormone (GnRH) analogue in IVF-ET therapy of severe endometriosis via openalex
Transvaginal ultrasonic needle-guided aspiration of endometriotic cysts before ovulation induction for in vitro fertilization via openalex
Treatment of endometriosis via openalex
Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist. via openalex
Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate. via openalex
Treatment of Endometriosis with Estrogen-Progestin Combination and Progestogens Alone via openalex
W66902808 via openalex
W2031495520 via openalex
W2019931933 via openalex
W2287757320 via openalex
W2396126095 via openalex
W2398218983 via openalex
W1965145195 via openalex
W2404777357 via openalex
W2407038112 via openalex
W2409164901 via openalex
W2412142226 via openalex
W2412454843 via openalex
W2414101651 via openalex
W2415098810 via openalex
W1792454541 via openalex
W2416488540 via openalex
W2416855537 via openalex
W2417044776 via openalex
W2419034820 via openalex

Cited by (33)

Source provenance

europepmc: last seen: 2026-06-11T06:19:48.454388+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:11:34.315996+00:00

License: CC0 · commercial use OK

[1] Abbreviated endometriosis-associated infertility correlates with in vitro fertilization success via openalex

[2] A Comparative Treatment Trial of Endometriosis Using the Gonadotrophin‐releasing Hormone Agonist, Nafarelin, and the Synthetic Steroid, Danazol via openalex

[3] Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex

[4] A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex

[5] A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis via openalex

[6] Bone mass in endometriosis patients treated with GnRH agonist implant or danazol. via openalex

[7] Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: A randomized clinical trial via openalex

[8] Buserelin versus danazol in the treatment of endometriosis-associated infertility via openalex

[9] Cholesterol fractions and apolipoproteins during endometriosis treatment by a gonadotrophin releasing hormone (GnRH) agonist implant or by danazol via openalex

[10] Comparison of different treatment modalities of endometriosis in infertile women via openalex

[11] Comparison of different treatment modalities of endometriosis in infertile women. via openalex

[12] Contraception: a risk factor for endometriosis. via openalex

[13] Cumulative pregnancy rates in infertile women with endometriosis. via openalex

[14] Cyclic use of Combination Oral Contraceptives and the Severity of Endometriosis via openalex

[15] Danazol and medroxyprogesterone acetate inefficacious in the treatment of infertility in endometriosis via openalex

[16] Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties via openalex

[17] Danazol inhibits steroidogenesis by the human ovary in vivo via openalex

[18] Dosage aspects of danazol therapy in endometriosis: Short-term and long-term effectiveness via openalex

[19] DYDROGESTERONE AND ENDOMETRIOSIS via openalex

[20] Effects of Progestin-Induced Pseudopregnancy on Endometriosis: Clinical and Microscopic Studies via openalex

[21] Efficacy of danazol treatment for minimal endometriosis in infertile women. A prospective, randomized study. via openalex

[22] Efficacy of intranasal or subcutaneous luteinizing hormone-releasing hormone agonist inhibition of ovarian function in the treatment of endometriosis via openalex

[23] Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis via openalex

[24] Endometriosis. via openalex

[25] Endometriosis 1991: a discussion document via openalex

[26] Endometriosis and infertility via openalex

[27] Endometriosis—Associated Infertility via openalex

[28] Endometriosis-associated infertility: evaluation of preoperative use of danazol, gestrinone, and buserelin. via openalex

[29] Endometriosis: Associations with Menorrhagia, Infertility and Oral Contraceptives via openalex

[30] Endometriosis therapy with medroxyprogesterone acetate. via openalex

[31] Epidemiology of endometriosis in women attending family planning clinics. via openalex

[32] Evaluation of oral medroxyprogesterone acetate in the treatment of endometriosis. via openalex

[33] Evidence of similar increases in bone turnover during nafarelin and danazol use in women with endometriosis via openalex

[34] Gamete intrafallopian transfer as treatment for infertility associated with endometriosis via openalex

[35] Gestogens and anti-gestogens as treatment of endometriosis via openalex

[36] Gonadotrophin releasing hormone agonist (buserelin) in the treatment of endometriosis: changes in the extent of the disease and in CA 125 serum levels after 6‐month therapy via openalex

[37] Gonadotropin releasing hormone agonist therapy and its effect on bone mass via openalex

[38] Hormonal and biochemical changes during treatment of endometriosis with the luteinizing hormone-releasing hormone (LH-RH) agonist <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mrow><mml:mo stretchy="false">[</mml:mo><mml:mtext>D</mml:mtext><mml:mo>-</mml:mo><mml:msup><mml:mrow><mml:mtext>Trp</mml:mtext></mml:mrow><mml:mn>6</mml:mn></mml:msup><mml:mo>,</mml:mo><mml:mtext>des</mml:mtext><mml:mo>-</mml:mo><mml:mtext>Gly</mml:mtext><mml:mo>-</mml:mo><mml:msubsup><mml:mrow><mml:mtext>NH</mml:mtext></mml:mrow><mml:mn>2</mml:mn><mml:mrow><mml:mn>10</mml:mn></mml:mrow></mml:msubsup><mml:mo stretchy="false">]</mml:mo></mml:mrow></mml:math>LH-RH ethylamide via openalex

[39] Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex

[40] Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis a rodent model via openalex

[41] Immunosuppressive effects of danazol in vitro via openalex

[42] Impact of gestrinone on the course of asymptomatic endometriosis. via openalex

[43] Is It Possible to Prevent Bone Loss in Young Women Treated with Luteinizing Hormone-Releasing Hormone Agonists? via openalex

[44] Lupron depot (leuprolide acetate for depot suspension) in the treatment of endometriosis: a randomized, placebo-controlled, double-blind study via openalex

[45] MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex

[46] Management of pelvic endometriosis with low-dose danazol via openalex

[47] Management of Pelvic Endometriosis with Low-Dose Danazol via openalex

[48] Medical Management of Endometriosis via openalex

[49] Medical treatment of endometriosis: a comparative trial. via openalex

[50] Medical treatment of endometriosis: a comparison of the suppressive effects of danazol and nafarelin on reproductive hormones via openalex

[51] Menotropin stimulation after prolonged gonadotropin releasing hormone agonist pretreatment for in vitro fertilization in patients with endometriosis via openalex

[52] Metabolic changes during medical treatment of endometriosis: Nafarelin acetate versus danazol via openalex

[53] Modern Approaches to Endometriosis via openalex

[54] Nafarelin for endometriosis: a large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex

[55] Nafarelin for endometriosis: A large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex

[56] OPINION: Endometriosis: a new approach is needed via openalex

[57] Periovulatory calcium channel blockade enhances reproductive performance in an animal model for endometriosis-associated subfertility. via openalex

[58] Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex

[59] Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery via openalex

[60] Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate via openalex

[61] Significant postmenopausal endometriosis. via openalex

[62] SIGNIFICANT POSTMENOPAUSAL ENDOMETRIOSIS via openalex

[63] Successful treatment of asymptomatic endometriosis: does it benefit infertile women? via openalex

[64] The effectiveness of danazol on subsequent fertility in minimal endometriosis via openalex

[65] The effect of endometriomas on in vitro fertilization outcome via openalex

[66] The effects of combining norethindrone with a gonadotropin-releasing hormone agonist in the treatment of symptomatic endometriosis via openalex

[67] The effects of combining norethindrone with a gonadotropin‐releasing hormone agonist in the treatment of symptomatic endometriosis via openalex

[68] The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer via openalex

[69] The morphologic effect of short-term medical therapy of endometriosis via openalex

[70] The Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise via openalex

[71] The role of definitive surgery and hormone replacement therapy in the treatment of endometriosis via openalex

[72] The second-look laparoscopy for evaluation of the result of medical treatment of endometriosis should not be performed during ovarian suppression via openalex

[73] The treatment of infertility associated with endometriosis by in vitro fertilization via openalex

[74] The use of danazol as a treatment of endometriosis via openalex

[75] THE USE OF STILBESTROL FOR ENDOMETRIOSIS via openalex

[76] The value of pre-treatment with gonadotrophin releasing hormone (GnRH) analogue in IVF-ET therapy of severe endometriosis via openalex

[77] Transvaginal ultrasonic needle-guided aspiration of endometriotic cysts before ovulation induction for in vitro fertilization via openalex

[78] Treatment of endometriosis via openalex

[79] Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist. via openalex

[80] Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate. via openalex

[81] Treatment of Endometriosis with Estrogen-Progestin Combination and Progestogens Alone via openalex

[82] W66902808 via openalex

[83] W2031495520 via openalex

[84] W2019931933 via openalex

[85] W2287757320 via openalex

[86] W2396126095 via openalex

[87] W2398218983 via openalex

[88] W1965145195 via openalex

[89] W2404777357 via openalex

[90] W2407038112 via openalex

[91] W2409164901 via openalex

[92] W2412142226 via openalex

[93] W2412454843 via openalex

[94] W2414101651 via openalex

[95] W2415098810 via openalex

[96] W1792454541 via openalex

[97] W2416488540 via openalex

[98] W2416855537 via openalex

[99] W2417044776 via openalex

[100] W2419034820 via openalex